-transparent.png){kind=logo}
The effects of cysteamine on duodenal mucosal blood flow and duodenal glycoprotein were studied during the development of duodenal ulceration in conscious rats. Cysteamine at an ulcerogenic dose (300 mg/kg s.c.) produced a remarkable decrease of duodenal mucosal blood flow which preceded the appearance of duodenal ulcers. The reduced blood flow was followed by a significant decrease of tissue levels of glycoprotein which also occurred prior to the time when duodenal injury had reached a maximum. Cysteamine was without significant effect on the rate of incorporation of 3H-glucosamine into duodenal glycoprotein at concentrations up to 10(-3) M. These results suggest that the reduction in duodenal mucosal blood flow in response to cysteamine could possibly contribute to a decrease of duodenal glycoprotein and that both may be at least in part responsible for the incidence of duodeno-ulcerogenecity.
Y Kurebayashi, and
M Asano, and
T Hashizume, and
A Akashi
January 1989,
Scandinavian journal of gastroenterology. Supplement,
Y Kurebayashi, and
M Asano, and
T Hashizume, and
A Akashi
June 1990,
Clinical and experimental pharmacology & physiology,
Y Kurebayashi, and
M Asano, and
T Hashizume, and
A Akashi
January 1982,
Advances in experimental medicine and biology,
Y Kurebayashi, and
M Asano, and
T Hashizume, and
A Akashi
October 1983,
Gut,
Y Kurebayashi, and
M Asano, and
T Hashizume, and
A Akashi
June 2009,
American journal of physiology. Gastrointestinal and liver physiology,
Y Kurebayashi, and
M Asano, and
T Hashizume, and
A Akashi
January 1992,
Pharmacology,
Y Kurebayashi, and
M Asano, and
T Hashizume, and
A Akashi
January 1991,
Digestion,
Y Kurebayashi, and
M Asano, and
T Hashizume, and
A Akashi
April 1987,
Annals of surgery,
Y Kurebayashi, and
M Asano, and
T Hashizume, and
A Akashi
January 1988,
Acta medica Hungarica,
Y Kurebayashi, and
M Asano, and
T Hashizume, and
A Akashi
January 1989,
Scandinavian journal of gastroenterology. Supplement,
