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We describe the use of a simplified bacterial fluctuation test to detect induced mutation, either incorporating liver microsomal or whole liver cell preparations. We have evaluated both types of test using three agents. The fluctuation assay seems somewhat slower, simpler and more sensitive than a conventional plating test with microsomes. A whole cell preparation appears marginally more effective than a microsomal fraction for metabolic activation of 9,10-dimethyl-1,2-benzanthracene, but rather less effective for benz(a)pyrene and 2-acetamidofluorene. Ultimately the usefulness of activation by whole cells may depend upon whether the method can give a correlation with carcinogenicity that is more quantitative than microsome methods and better reflects organ and species specificity.
M H Green, and
B A Bridges, and
A M Rogers, and
G Horspool, and
W J Muriel, and
J W Bridges, and
J R Fry
October 1981,
Life sciences,
M H Green, and
B A Bridges, and
A M Rogers, and
G Horspool, and
W J Muriel, and
J W Bridges, and
J R Fry
April 1980,
Mutation research,
M H Green, and
B A Bridges, and
A M Rogers, and
G Horspool, and
W J Muriel, and
J W Bridges, and
J R Fry
July 1977,
Mutation research,
M H Green, and
B A Bridges, and
A M Rogers, and
G Horspool, and
W J Muriel, and
J W Bridges, and
J R Fry
April 2010,
American journal of clinical pathology,
M H Green, and
B A Bridges, and
A M Rogers, and
G Horspool, and
W J Muriel, and
J W Bridges, and
J R Fry
December 1980,
Mutation research,
M H Green, and
B A Bridges, and
A M Rogers, and
G Horspool, and
W J Muriel, and
J W Bridges, and
J R Fry
April 1975,
Mutation research,
M H Green, and
B A Bridges, and
A M Rogers, and
G Horspool, and
W J Muriel, and
J W Bridges, and
J R Fry
July 1976,
Biochemical pharmacology,
M H Green, and
B A Bridges, and
A M Rogers, and
G Horspool, and
W J Muriel, and
J W Bridges, and
J R Fry
March 1979,
International journal of cancer,
M H Green, and
B A Bridges, and
A M Rogers, and
G Horspool, and
W J Muriel, and
J W Bridges, and
J R Fry
January 1990,
Chemico-biological interactions,
M H Green, and
B A Bridges, and
A M Rogers, and
G Horspool, and
W J Muriel, and
J W Bridges, and
J R Fry
May 1984,
Biochemical pharmacology,
