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To determine the effect of dialysate osmolarity on peritoneal dialysis drug transfer, peritoneal dialysis clearances of theophylline, phenobarbital, and tobramycin were determined in 10 rabbits using dialysate containing 1.5 and 4.25% glucose. Urea and creatinine clearances were also obtained for comparison. Under similar dialysis conditions, the peritoneal clearances of the three drugs remained unchanged for the two types of dialysate. In contrast, the peritoneal clearances of urea and creatinine were significantly higher with the use of 4.25% glucose dialysate (p less than 0.001). Thus, peritoneal dialysis clearances of theophylline, phenobarbital and tobramycin are not significantly affected by hypertonicity-induced ultrafiltration during acute peritoneal dialysis.
A H Lau, and
E Chow-Tung, and
F K Assadi, and
L Fornell, and
E John
January 1980,
The Yale journal of biology and medicine,
A H Lau, and
E Chow-Tung, and
F K Assadi, and
L Fornell, and
E John
January 1994,
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis,
A H Lau, and
E Chow-Tung, and
F K Assadi, and
L Fornell, and
E John
January 1988,
Nephron,
A H Lau, and
E Chow-Tung, and
F K Assadi, and
L Fornell, and
E John
January 1999,
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis,
A H Lau, and
E Chow-Tung, and
F K Assadi, and
L Fornell, and
E John
November 1987,
The Journal of clinical investigation,
A H Lau, and
E Chow-Tung, and
F K Assadi, and
L Fornell, and
E John
January 1986,
ASAIO transactions,
A H Lau, and
E Chow-Tung, and
F K Assadi, and
L Fornell, and
E John
October 1990,
The International journal of artificial organs,
A H Lau, and
E Chow-Tung, and
F K Assadi, and
L Fornell, and
E John
January 1979,
Transactions - American Society for Artificial Internal Organs,
A H Lau, and
E Chow-Tung, and
F K Assadi, and
L Fornell, and
E John
January 2000,
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis,
A H Lau, and
E Chow-Tung, and
F K Assadi, and
L Fornell, and
E John
March 1983,
Vnitrni lekarstvi,
