-transparent.png){kind=logo}
The effect of two antacids on the bioavailability of paracetamol has been investigated in 12 young healthy volunteers. Following a random cross over design, each subject swallowed, on three separate occasions, one weak apart, 500 mg paracetamol alone, or together with two different aluminium hydroxide, magnesium hydroxide preparations (Dimalan and Maalox). Plasma paracetamol levels were measured by HPLC. The bioavailability of paracetamol was not altered by either antacid, but they both delayed the time to peak plasma concentration (0.85 h; 1.43 h; 1.25 h, without antacid, with Dimalan and with Maalox respectively). The peak plasma concentration was not affected by concurrent antacid administration.
H Albin, and
F Demotes-Mainard, and
G Vinçon, and
A Bedjaoui, and
B Begaud
January 1981,
Therapeutic drug monitoring,
H Albin, and
F Demotes-Mainard, and
G Vinçon, and
A Bedjaoui, and
B Begaud
December 1987,
Il Farmaco; edizione pratica,
H Albin, and
F Demotes-Mainard, and
G Vinçon, and
A Bedjaoui, and
B Begaud
January 1984,
Therapie,
H Albin, and
F Demotes-Mainard, and
G Vinçon, and
A Bedjaoui, and
B Begaud
December 1977,
Journal of pharmacokinetics and biopharmaceutics,
H Albin, and
F Demotes-Mainard, and
G Vinçon, and
A Bedjaoui, and
B Begaud
July 1979,
Archives of neurology,
H Albin, and
F Demotes-Mainard, and
G Vinçon, and
A Bedjaoui, and
B Begaud
July 1980,
Archives of neurology,
H Albin, and
F Demotes-Mainard, and
G Vinçon, and
A Bedjaoui, and
B Begaud
September 1989,
Zhonghua nei ke za zhi,
H Albin, and
F Demotes-Mainard, and
G Vinçon, and
A Bedjaoui, and
B Begaud
April 1994,
Antimicrobial agents and chemotherapy,
H Albin, and
F Demotes-Mainard, and
G Vinçon, and
A Bedjaoui, and
B Begaud
January 1989,
Drugs under experimental and clinical research,
H Albin, and
F Demotes-Mainard, and
G Vinçon, and
A Bedjaoui, and
B Begaud
January 1984,
European journal of clinical pharmacology,
