Biomaterial Database

Use of 2,3-dimercaptopropane-1-sulfonate in treatment of lead poisoning in children. 1985

J J Chisolm, and D J Thomas

2,3-Dimercaptopropane-1-sulfonate (DMPS) is a water-soluble metal complexing agent. Administration to lead-poisoned children of 5-day courses of 200 or 400 mg of DMPS per m2 surface area per day given p.o. in divided doses resulted in a significant decline in the concentration of lead in blood. DMPS treatment did not significantly alter the concentrations of zinc or copper in plasma. Urinary excretion of lead, zinc and copper was increased by DMPS administration and these increases were sustained throughout the 5-day course of treatment. No significant changes in hepatic, renal or hematological function were found in DMPS-treated children and no side effects attributable to DMPS were noted. It is concluded that a 5-day course of DMPS given p.o. may be safe and effective in the treatment of asymptomatic lead poisoning in children.

UI	MeSH Term	Description	Entries
D007854	Lead	A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.
D007855	Lead Poisoning	Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of LEAD or lead compounds.	Poisoning, Lead,Lead Poisonings,Poisonings, Lead
D008297	Male		Males
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D003300	Copper	A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.	Copper-63,Copper 63
D004112	Dimercaprol	An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.	2,3-Dimercaptopropanol,2,3-Dithiopropan-1-o1,B.A.L.,BAL in Oil,British Anti-Lewisite,British Anti-Lewisite Agent,Cadmium 2,3-Dimercaptopropanol,Dicaptol,2,3 Dimercaptopropanol,2,3 Dithiopropan 1 o1,2,3-Dimercaptopropanol, Cadmium,Anti-Lewisite Agent, British,Anti-Lewisite, British,British Anti Lewisite,British Anti Lewisite Agent,Cadmium 2,3 Dimercaptopropanol,Oil, BAL in,in Oil, BAL
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001219	Aspartate Aminotransferases	Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.	Aspartate Aminotransferase,Aspartate Transaminase,Glutamic-Oxaloacetic Transaminase,SGOT,Aspartate Apoaminotransferase,Glutamate-Aspartate Transaminase,L-Aspartate-2-Oxoglutarate Aminotransferase,Serum Glutamic-Oxaloacetic Transaminase,Aminotransferase, Aspartate,Aminotransferase, L-Aspartate-2-Oxoglutarate,Aminotransferases, Aspartate,Apoaminotransferase, Aspartate,Glutamate Aspartate Transaminase,Glutamic Oxaloacetic Transaminase,Glutamic-Oxaloacetic Transaminase, Serum,L Aspartate 2 Oxoglutarate Aminotransferase,Serum Glutamic Oxaloacetic Transaminase,Transaminase, Aspartate,Transaminase, Glutamate-Aspartate,Transaminase, Glutamic-Oxaloacetic,Transaminase, Serum Glutamic-Oxaloacetic
D014494	Unithiol	A chelating agent used as an antidote to heavy metal poisoning.	2,3-Dimercapto-1-propanesulfonic Acid,2,3-Dimercaptopropane 1-Sodium Sulfonate,2,3-Dimercaptopropane-1-sulfonate Sodium,2,3-Dimercaptopropanesulfonic Acid,DMPS,DMPS-Heyl,Dimaval,Mercuval,Sodium 2,3-Dimercaptopropane Sulfonate,Sodium 2,3-Dithiopropanesulfate,Unitiol,1-Sodium Sulfonate, 2,3-Dimercaptopropane,2,3 Dimercapto 1 propanesulfonic Acid,2,3 Dimercaptopropane 1 Sodium Sulfonate,2,3 Dimercaptopropane 1 sulfonate Sodium,2,3 Dimercaptopropanesulfonic Acid,2,3-Dimercaptopropane Sulfonate, Sodium,2,3-Dithiopropanesulfate, Sodium,DMPS Heyl