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Treatment with ornithine decarboxylase inhibitors leads to a marked increase of decarboxylated S-adenosylmethionine (dc-SAM) in various tissues, accompanied by the concomitant formation of a metabolite of dc-SAM. This metabolite has been isolated from rat prostate samples by a combination of chromatographic procedures. The use of IH-NMR and of fast atom bombardment mass spectometry and the synthesis of an authentic sample allowed the unambiguous characterization of this unknown compound as the N-acetyl derivative of dc-SAM. A reverse-phase high performance liquid chromatography procedure was developed for the separation of dc-SAM and its N-acetyl derivative into their diastereomers resulting from the chiral sulfonium group.
J Wagner, and
Y Hirth, and
F Piriou, and
D Zakett, and
N Claverie, and
C Danzin
July 1980,
The Journal of biological chemistry,
J Wagner, and
Y Hirth, and
F Piriou, and
D Zakett, and
N Claverie, and
C Danzin
January 1983,
Methods in enzymology,
J Wagner, and
Y Hirth, and
F Piriou, and
D Zakett, and
N Claverie, and
C Danzin
January 1986,
Biochemistry,
J Wagner, and
Y Hirth, and
F Piriou, and
D Zakett, and
N Claverie, and
C Danzin
February 1980,
Bollettino della Societa italiana di biologia sperimentale,
J Wagner, and
Y Hirth, and
F Piriou, and
D Zakett, and
N Claverie, and
C Danzin
July 1980,
Chemical & pharmaceutical bulletin,
J Wagner, and
Y Hirth, and
F Piriou, and
D Zakett, and
N Claverie, and
C Danzin
January 2011,
The Biochemical journal,
J Wagner, and
Y Hirth, and
F Piriou, and
D Zakett, and
N Claverie, and
C Danzin
February 1987,
Cancer research,
J Wagner, and
Y Hirth, and
F Piriou, and
D Zakett, and
N Claverie, and
C Danzin
March 1987,
Journal of chromatography,
J Wagner, and
Y Hirth, and
F Piriou, and
D Zakett, and
N Claverie, and
C Danzin
July 1986,
Journal of biochemistry,
J Wagner, and
Y Hirth, and
F Piriou, and
D Zakett, and
N Claverie, and
C Danzin
February 1982,
The Biochemical journal,
