BIOMAT Database Logo BIOMAT Database Logo

Blood nicotine, smoke exposure and tobacco withdrawal symptoms. 1985

D K Hatsukami, and J R Hughes, and R W Pickens

The relationship between tobacco withdrawal symptoms and pre- and post-cigarette blood nicotine levels, pre-cigarette cotinine levels, change in nicotine level from pre- to post-cigarette, half-life for nicotine, and total smoke exposure was examined in 20 smokers. Subjects' reports of craving for cigarettes were significantly related to blood nicotine/cotinine levels and change in nicotine level from pre- to post-cigarette; questionnaire measures of confusion and number of awakenings during sleep was related to half-life for nicotine; and number of awakenings during sleep was related to behavioral measures of total smoke exposure. These results suggests some symptoms of tobacco withdrawal are related to nicotine deprivation while others are not.

UI MeSH Term Description Entries
D008297 Male Males
D009538 Nicotine Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke. Nicotine Bitartrate,Nicotine Tartrate
D003221 Confusion A mental state characterized by bewilderment, emotional disturbance, lack of clear thinking, and perceptual disorientation. Confusional State,Bewilderment,Confusion, Post-Ictal,Confusion, Reactive,Disorientation,Confusion, Post Ictal,Confusional States,Post-Ictal Confusion,Reactive Confusion,State, Confusional,States, Confusional
D003367 Cotinine The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties. Scotine
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D012893 Sleep Wake Disorders Abnormal sleep-wake schedule or pattern associated with the CIRCADIAN RHYTHM which affect the length, timing, and/or rigidity of the sleep-wake cycle relative to the day-night cycle. Sleep Disorders,Long Sleeper Syndrome,Short Sleep Phenotype,Short Sleeper Syndrome,Sleep-Related Neurogenic Tachypnea,Subwakefullness Syndrome,Disorder, Sleep,Disorder, Sleep Wake,Disorders, Sleep,Disorders, Sleep Wake,Long Sleeper Syndromes,Neurogenic Tachypnea, Sleep-Related,Neurogenic Tachypneas, Sleep-Related,Phenotype, Short Sleep,Phenotypes, Short Sleep,Short Sleep Phenotypes,Short Sleeper Syndromes,Sleep Disorder,Sleep Phenotypes, Short,Sleep Related Neurogenic Tachypnea,Sleep Wake Disorder,Sleep-Related Neurogenic Tachypneas,Sleeper Syndrome, Long,Sleeper Syndrome, Short,Sleeper Syndromes, Long,Sleeper Syndromes, Short,Subwakefullness Syndromes,Syndrome, Long Sleeper,Syndrome, Short Sleeper,Syndrome, Subwakefullness,Syndromes, Long Sleeper,Syndromes, Short Sleeper,Syndromes, Subwakefullness,Tachypnea, Sleep-Related Neurogenic,Tachypneas, Sleep-Related Neurogenic,Wake Disorder, Sleep,Wake Disorders, Sleep
D013375 Substance Withdrawal Syndrome Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug. Drug Withdrawal Symptoms,Withdrawal Symptoms,Drug Withdrawal Symptom,Substance Withdrawal Syndromes,Symptom, Drug Withdrawal,Symptom, Withdrawal,Symptoms, Drug Withdrawal,Symptoms, Withdrawal,Syndrome, Substance Withdrawal,Syndromes, Substance Withdrawal,Withdrawal Symptom,Withdrawal Symptom, Drug,Withdrawal Symptoms, Drug,Withdrawal Syndrome, Substance,Withdrawal Syndromes, Substance
D014029 Tobacco Use Disorder Tobacco used to the detriment of a person's health or social functioning. Tobacco dependence is included. Nicotine Addiction,Nicotine Dependence,Nicotine Use Disorder,Tobacco Dependence,Tobacco-Use Disorder,Addiction, Nicotine,Dependence, Nicotine,Dependence, Tobacco,Disorder, Nicotine Use,Disorder, Tobacco Use,Disorder, Tobacco-Use,Nicotine Addictions,Nicotine Use Disorders,Tobacco Use Disorders

Related Publications

D K Hatsukami, and J R Hughes, and R W Pickens
[Nicotine addiction and environmental tobacco smoke exposure].
January 2011, Tuberkuloz ve toraks,
D K Hatsukami, and J R Hughes, and R W Pickens
Tobacco smoke exposure induces nicotine dependence in rats.
January 2010, Psychopharmacology,
D K Hatsukami, and J R Hughes, and R W Pickens
Secondhand tobacco smoke exposure, nicotine dependence, and smoking cessation.
January 2008, Public health nursing (Boston, Mass.),
D K Hatsukami, and J R Hughes, and R W Pickens
Chronic exposure to cigarette smoke extract increases nicotine withdrawal symptoms in adult and adolescent male rats.
January 2023, Advances in drug and alcohol research,
D K Hatsukami, and J R Hughes, and R W Pickens
Nicotine replacement: ten-week effects on tobacco withdrawal symptoms.
January 1989, Psychopharmacology,
D K Hatsukami, and J R Hughes, and R W Pickens
Impact of Tobacco Smoke and Nicotine Exposure on Lung Development.
February 2016, Chest,
D K Hatsukami, and J R Hughes, and R W Pickens
Adolescent nicotine and tobacco smoke exposure enhances nicotine self-administration in female rats.
October 2020, Neuropharmacology,
D K Hatsukami, and J R Hughes, and R W Pickens
Nicotine reduction in tobacco and tobacco smoke.
June 1968, National Cancer Institute monograph,
D K Hatsukami, and J R Hughes, and R W Pickens
Olanzapine reduces urge to smoke and nicotine withdrawal symptoms in community smokers.
June 2008, Experimental and clinical psychopharmacology,
D K Hatsukami, and J R Hughes, and R W Pickens
Toenail nicotine levels as a biomarker of tobacco smoke exposure.
November 2002, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,
Copied contents to your clipboard!