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Thyroidal secretion of 3,3',5'-triiodothyronine (reverse T3, rT3) and its control by TSH was assessed by measuring (1) arterio-venous hormone gradients in patients undergoing surgery, (2) changes of hormone concentrations after induction of anaesthesia, and (3) changes induced by TRH administration. In ten patients in whom thyroid activity was under TSH control (parathyroidectomy and non-toxic goitre) increased thyroid vein/carotid artery ratios (TV/CA) for rT3 (mean TV/CA ratio 2.53) were found when compared to six patients with non-toxic goitre on suppressive doses of T4 (mean TV/CA ratio, 1.27) (P less than 0.05). The mean calculated operative secretion rate of rT3 was 12.5 microgram/day but only 2.4 microgram/day in patients receiving T4. In thirteen patients undergoing elective surgery induction of anaesthesia significantly increased rT3 levels. In nine euthyroid adults intravenous TRH (200 microgram) increased peripheral venous rT3 levels between 3 h (P less than 0.005) and 8 h (P less than 0.05) after the injection. It is concluded that significant amounts of rT3 are secreted by the thyroid gland at operation and this is, in part, under TSH control.
M J Hooper, and
J G Ratcliffe, and
W A Ratcliffe, and
J Marshall, and
R E Young, and
G Ngaei, and
D H Clark
January 1979,
Bulletin de l'Academie polonaise des sciences. Serie des sciences biologiques,
M J Hooper, and
J G Ratcliffe, and
W A Ratcliffe, and
J Marshall, and
R E Young, and
G Ngaei, and
D H Clark
May 1987,
Acta endocrinologica,
M J Hooper, and
J G Ratcliffe, and
W A Ratcliffe, and
J Marshall, and
R E Young, and
G Ngaei, and
D H Clark
July 1976,
The Journal of clinical investigation,
M J Hooper, and
J G Ratcliffe, and
W A Ratcliffe, and
J Marshall, and
R E Young, and
G Ngaei, and
D H Clark
January 1991,
The Journal of clinical endocrinology and metabolism,
M J Hooper, and
J G Ratcliffe, and
W A Ratcliffe, and
J Marshall, and
R E Young, and
G Ngaei, and
D H Clark
January 1958,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
M J Hooper, and
J G Ratcliffe, and
W A Ratcliffe, and
J Marshall, and
R E Young, and
G Ngaei, and
D H Clark
April 1978,
Endocrinology,
M J Hooper, and
J G Ratcliffe, and
W A Ratcliffe, and
J Marshall, and
R E Young, and
G Ngaei, and
D H Clark
May 1977,
The Journal of clinical endocrinology and metabolism,
M J Hooper, and
J G Ratcliffe, and
W A Ratcliffe, and
J Marshall, and
R E Young, and
G Ngaei, and
D H Clark
May 1989,
Acta endocrinologica,
M J Hooper, and
J G Ratcliffe, and
W A Ratcliffe, and
J Marshall, and
R E Young, and
G Ngaei, and
D H Clark
November 1975,
Endocrinology,
M J Hooper, and
J G Ratcliffe, and
W A Ratcliffe, and
J Marshall, and
R E Young, and
G Ngaei, and
D H Clark
January 1979,
Endokrynologia Polska,
