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Precipitating antibodies in dermatophytosis demonstrated by crossed immunoelectrophoresis. 1979

E Svejgaard, and A H Christiansen

A total of 289 serum specimens from 262 patients with dermatophytosis were studied, using crossed immunoelectrophoresis with an intermediate gel. Rabbit antidermatophyte antisera were used as reference, and the antigens were water soluble extracts of Trichophyton (T) rubrum, T. mentagrophytes, Microsporum (M.) canis or Epidermophyton (E.) floccosum. Each serum was tested against the dermatophyte antigen corresponding to the infectious agent of the patient in question. Antidermatophyte antibodies could be demonstrated in 25 (9.5%) of the patients, and these were particularly frequent in patients with highly inflammatory lesions and those with chronic dermatophytosis caused by T. rubrum. Antibodies were detected in all four patients with kerion Celsi. Nine patients, five with acute dermatophytosis and four with chronic disease, who had precipitating antibodies at the initial examination were studied several times during the course of the disease. While the antibodies disappeared in all the patients with acute disease, they persisted in those with chronic dermatophytosis. The human antibodies showed marked cross reactivity with T. rubrum, T. mentagrophytes, M. canis and E. floccosum.

UI MeSH Term Description Entries
D007106 Immune Sera Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen. Antisera,Immune Serums,Sera, Immune,Serums, Immune
D007123 Immunoelectrophoresis, Two-Dimensional Immunoelectrophoresis in which a second electrophoretic transport is performed on the initially separated antigen fragments into an antibody-containing medium in a direction perpendicular to the first electrophoresis. Immunoelectrophoresis, Crossed,Immunoelectrophoresis, 2-D,Immunoelectrophoresis, 2D,2-D Immunoelectrophoresis,2D Immunoelectrophoresis,Crossed Immunoelectrophoresis,Immunoelectrophoresis, 2 D,Immunoelectrophoresis, Two Dimensional,Two-Dimensional Immunoelectrophoresis
D011232 Chemical Precipitation The formation of a solid in a solution as a result of a chemical reaction or the aggregation of soluble substances into complexes large enough to fall out of solution. Precipitation, Chemical
D003881 Dermatomycoses Superficial infections of the skin or its appendages by any of various fungi. Skin Diseases, Fungal,Dermatomycosis,Dermatophyte Infection,Fungal Skin Diseases
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000908 Antibodies, Fungal Immunoglobulins produced in a response to FUNGAL ANTIGENS. Fungal Antibodies
D000946 Antigens, Fungal Substances of fungal origin that have antigenic activity. Fungal Antigen,Fungal Antigens,Antigen, Fungal

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