Effects of carbon tetrachloride on isolated rat hepatocytes. Inhibition of protein and lipoprotein secretion. 1979

E Gravela, and E Albano, and M U Dianzani, and G Poli, and T F Slater

The effects of carbon tetrachloride on protein and lipoprotein secretion, and on lipid peroxidation, have been investigated in isolated rat hepatocytes. It was found that although the free-radical scavenger promethazine completely suppressed the increased peroxidation produced by carbon tetrachloride, it had no effect on the inhibitory action of carbon tetrachloride on lipoprotein secretion. In consequence, the latter effect of carbon tetrachloride does not appear to be mediated through a peroxidative stage.

UI MeSH Term Description Entries
D008074 Lipoproteins Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes. Circulating Lipoproteins,Lipoprotein,Lipoproteins, Circulating
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D010545 Peroxides A group of compounds that contain a bivalent O-O group, i.e., the oxygen atoms are univalent. They can either be inorganic or organic in nature. Such compounds release atomic (nascent) oxygen readily. Thus they are strong oxidizing agents and fire hazards when in contact with combustible materials, especially under high-temperature conditions. The chief industrial uses of peroxides are as oxidizing agents, bleaching agents, and initiators of polymerization. (From Hawley's Condensed Chemical Dictionary, 11th ed) Peroxide
D011506 Proteins Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. Gene Products, Protein,Gene Proteins,Protein,Protein Gene Products,Proteins, Gene
D002251 Carbon Tetrachloride A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed) Tetrachloromethane,Tetrachloride, Carbon
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012636 Secretory Rate The amount of a substance secreted by cells or by a specific organ or organism over a given period of time; usually applies to those substances which are formed by glandular tissues and are released by them into biological fluids, e.g., secretory rate of corticosteroids by the adrenal cortex, secretory rate of gastric acid by the gastric mucosa. Rate, Secretory,Rates, Secretory,Secretory Rates
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D066298 In Vitro Techniques Methods to study reactions or processes taking place in an artificial environment outside the living organism. In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In

Related Publications

E Gravela, and E Albano, and M U Dianzani, and G Poli, and T F Slater
January 1988, Virchows Archiv. B, Cell pathology including molecular pathology,
E Gravela, and E Albano, and M U Dianzani, and G Poli, and T F Slater
June 1988, Biochemical and biophysical research communications,
E Gravela, and E Albano, and M U Dianzani, and G Poli, and T F Slater
January 1981, Virchows Archiv. B, Cell pathology including molecular pathology,
E Gravela, and E Albano, and M U Dianzani, and G Poli, and T F Slater
August 1984, Biochemical pharmacology,
E Gravela, and E Albano, and M U Dianzani, and G Poli, and T F Slater
June 1987, Experimental and molecular pathology,
E Gravela, and E Albano, and M U Dianzani, and G Poli, and T F Slater
August 1984, Biochemical pharmacology,
E Gravela, and E Albano, and M U Dianzani, and G Poli, and T F Slater
August 1986, Arzneimittel-Forschung,
E Gravela, and E Albano, and M U Dianzani, and G Poli, and T F Slater
June 1991, Toxicology and applied pharmacology,
E Gravela, and E Albano, and M U Dianzani, and G Poli, and T F Slater
January 1981, Toxicology letters,
E Gravela, and E Albano, and M U Dianzani, and G Poli, and T F Slater
October 1986, Biochemical pharmacology,
Copied contents to your clipboard!