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Isolated rat hepatocytes were incubated with carbon tetrachloride (CCl4) at a concentration of 0.2 mol CCl4/ml of incubation medium. The ultrastructural alterations and release of lactate dehydrogenase (LDH) and glutamate-oxaloacetate transaminase (GOT), were recorded after different periods of incubation. After 5 min incubation with CCl4, morphological changes observed by electron microscopy, involved the plasma membrane. The endoplasmic reticulum and mitochondria were altered later. These morphological alterations were accompanied by an early release of LDH and GOT into the incubation medium. It is concluded that, in contrast with its in vivo effects, in vitro CCl4 can induced an early morphological alteration of the hepatocyte plasma membrane before damaging the endoplasmic reticulum.
D Perrissoud, and
G Auderset, and
O Reymond, and
M F Maignan
February 1978,
Experimental and molecular pathology,
D Perrissoud, and
G Auderset, and
O Reymond, and
M F Maignan
January 1996,
Drugs under experimental and clinical research,
D Perrissoud, and
G Auderset, and
O Reymond, and
M F Maignan
June 1987,
Experimental and molecular pathology,
D Perrissoud, and
G Auderset, and
O Reymond, and
M F Maignan
January 1981,
Toxicology letters,
D Perrissoud, and
G Auderset, and
O Reymond, and
M F Maignan
January 2006,
Redox report : communications in free radical research,
D Perrissoud, and
G Auderset, and
O Reymond, and
M F Maignan
January 1988,
Virchows Archiv. B, Cell pathology including molecular pathology,
D Perrissoud, and
G Auderset, and
O Reymond, and
M F Maignan
October 1986,
Biochemical pharmacology,
D Perrissoud, and
G Auderset, and
O Reymond, and
M F Maignan
January 1981,
Toxicology,
D Perrissoud, and
G Auderset, and
O Reymond, and
M F Maignan
February 1960,
A.M.A. archives of industrial health,
D Perrissoud, and
G Auderset, and
O Reymond, and
M F Maignan
February 1979,
The Biochemical journal,
