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The effect of long-term prophylaxis of duodenal ulceration with cimetidine was tested in a double blind trial. In 20 patients treated with cimetidine there was a four-fold reduction in the relapse rate when compared with 18 placebo-treated patients. However, treatment of the acute phase of ulceration with cimetidine increased the recurrence rate more than five-fold when compared with placebo treatment. Slow healing of ulceration was followed by a two-fold incidence of recurrence when compared with rapid healing. From the results it is concluded that recurrence occurs in patients after slow healing and (or) previous cimetidine treatment if long-term prophylaxis with cimetidine is not carried out.
A Sonnenberg, and
K Kiene, and
K B Weber, and
S Pelloni, and
P Peter, and
M Wienbeck, and
G Strohmeyer, and
A L Blum
November 1976,
Deutsche medizinische Wochenschrift (1946),
A Sonnenberg, and
K Kiene, and
K B Weber, and
S Pelloni, and
P Peter, and
M Wienbeck, and
G Strohmeyer, and
A L Blum
March 1980,
Gastroenterologie clinique et biologique,
A Sonnenberg, and
K Kiene, and
K B Weber, and
S Pelloni, and
P Peter, and
M Wienbeck, and
G Strohmeyer, and
A L Blum
July 1982,
Deutsche medizinische Wochenschrift (1946),
A Sonnenberg, and
K Kiene, and
K B Weber, and
S Pelloni, and
P Peter, and
M Wienbeck, and
G Strohmeyer, and
A L Blum
January 1982,
Schweizerische medizinische Wochenschrift,
A Sonnenberg, and
K Kiene, and
K B Weber, and
S Pelloni, and
P Peter, and
M Wienbeck, and
G Strohmeyer, and
A L Blum
September 1980,
Lijecnicki vjesnik,
A Sonnenberg, and
K Kiene, and
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S Pelloni, and
P Peter, and
M Wienbeck, and
G Strohmeyer, and
A L Blum
January 1981,
Anesthesie, analgesie, reanimation,
A Sonnenberg, and
K Kiene, and
K B Weber, and
S Pelloni, and
P Peter, and
M Wienbeck, and
G Strohmeyer, and
A L Blum
January 1982,
Deutsche medizinische Wochenschrift (1946),
A Sonnenberg, and
K Kiene, and
K B Weber, and
S Pelloni, and
P Peter, and
M Wienbeck, and
G Strohmeyer, and
A L Blum
September 1979,
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association,
A Sonnenberg, and
K Kiene, and
K B Weber, and
S Pelloni, and
P Peter, and
M Wienbeck, and
G Strohmeyer, and
A L Blum
January 1978,
Deutsche medizinische Wochenschrift (1946),
A Sonnenberg, and
K Kiene, and
K B Weber, and
S Pelloni, and
P Peter, and
M Wienbeck, and
G Strohmeyer, and
A L Blum
September 1984,
The New England journal of medicine,
