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The effect of pirenzepine and cimetidine on healing, symptoms, and relapse rate of duodenal ulcer was studied in a placebo controlled double blind trial. With regard to symptoms, cimetidine (1 g daily) was superior at the beginning of therapy to a low dose of pirenzepine (75 mg daily) and to placebo. No significant differences in ulcer healing were found between the 3 treatment groups. The relapse rate after treatment with pirenzepine was lower than after treatment with cimetidine.
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