-transparent.png){kind=logo}
Collagen biosynthesis was measured in skin biopsies taken from 13 patients with rheumatoid arthritis before and after at least 6 months' continuous treatment with D-penicillamine, 1.0 g/day. There was a significant 36% reduction in mean collagen biosynthesis (p less than 0.0125) as assayed by 14C-hydroxyproline formation from 14C-proline during 24 h of tissue culture. The changes in 14C-hydroxyproline formation were correlated with the total doses of D-penicillamine taken (r = 0.71, p less than 0.01) and the falls in ESR (r = 0.72, p less than 0.01). No significant change in general protein syntehsis was observed. 500 microgram/mlD-penicillamine added to skil cultures in vitro inhibited both collagen and general protein synthesis (p less than 0.01). It is suggested that the clinical improvement induced by D-penicillamine could reflect an inhibition of collagen proliferation in the synovium.
D Schorn, and
M J Francis, and
M Loudon, and
A G Mowat
June 1984,
Annals of the rheumatic diseases,
D Schorn, and
M J Francis, and
M Loudon, and
A G Mowat
January 1981,
The Journal of rheumatology. Supplement,
D Schorn, and
M J Francis, and
M Loudon, and
A G Mowat
February 1976,
Agents and actions,
D Schorn, and
M J Francis, and
M Loudon, and
A G Mowat
January 1982,
La Revue de medecine interne,
D Schorn, and
M J Francis, and
M Loudon, and
A G Mowat
January 1981,
Revue du rhumatisme et des maladies osteo-articulaires,
D Schorn, and
M J Francis, and
M Loudon, and
A G Mowat
October 1979,
Sovetskaia meditsina,
D Schorn, and
M J Francis, and
M Loudon, and
A G Mowat
January 1981,
The Journal of rheumatology. Supplement,
D Schorn, and
M J Francis, and
M Loudon, and
A G Mowat
November 1978,
Die Medizinische Welt,
D Schorn, and
M J Francis, and
M Loudon, and
A G Mowat
March 1983,
Annals of internal medicine,
D Schorn, and
M J Francis, and
M Loudon, and
A G Mowat
January 1981,
La Revue de medecine interne,
