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The mechanism of D-penicillamine induced thrombocytopenia in rheumatoid arthritis was investigated by measuring platelet life-span and platelet production rate in 2 groups of rheumatoid arthritis patients treated with 250-750 mg/day D-penicillamine, 14 with a normal platelet count and 9 with thrombocytopenia (platelet count 50-130 X 10(9)/1). Age matched control patients not treated with D-penicillamine included 14 with rheumatoid arthritis and 9 with osteoarthritis. The platelet life-span was normal, but platelet production rate was significantly reduced in the thrombocytopenic patients, suggesting that D-penicillamine causes thrombocytopenia through bone marrow suppression.
D Thomas, and
A S Gallus, and
P M Brooks, and
R Tampi, and
R Geddes, and
W Hill
January 1981,
The Journal of rheumatology. Supplement,
D Thomas, and
A S Gallus, and
P M Brooks, and
R Tampi, and
R Geddes, and
W Hill
February 1976,
Agents and actions,
D Thomas, and
A S Gallus, and
P M Brooks, and
R Tampi, and
R Geddes, and
W Hill
January 1982,
La Revue de medecine interne,
D Thomas, and
A S Gallus, and
P M Brooks, and
R Tampi, and
R Geddes, and
W Hill
January 1981,
Revue du rhumatisme et des maladies osteo-articulaires,
D Thomas, and
A S Gallus, and
P M Brooks, and
R Tampi, and
R Geddes, and
W Hill
October 1979,
Sovetskaia meditsina,
D Thomas, and
A S Gallus, and
P M Brooks, and
R Tampi, and
R Geddes, and
W Hill
January 1979,
Scandinavian journal of rheumatology,
D Thomas, and
A S Gallus, and
P M Brooks, and
R Tampi, and
R Geddes, and
W Hill
January 1981,
The Journal of rheumatology. Supplement,
D Thomas, and
A S Gallus, and
P M Brooks, and
R Tampi, and
R Geddes, and
W Hill
November 1978,
Die Medizinische Welt,
D Thomas, and
A S Gallus, and
P M Brooks, and
R Tampi, and
R Geddes, and
W Hill
March 1983,
Annals of internal medicine,
D Thomas, and
A S Gallus, and
P M Brooks, and
R Tampi, and
R Geddes, and
W Hill
January 1981,
La Revue de medecine interne,
