Hydrogels prepared from poly(hydroxyethyl methacrylate) are biocompatible and highly permeable to low molecular weight solutes. Permeation rates can be varied by altering the cross-linker concentration or using copolymers; the latter are chosen to alter the hydrogel equilibrium hydration. These factors suggest that hydrogels are good candidates for controlled-release drug delivery devices. Hydrogels may be synthesized using various temperatures, initiators (nature and concentration), and solvents (nature and concentration). This study demonstrated that progesterone permeation through poly(hydroxyethyl methacrylate) films is independent of polymerization solvent (nature and concentration) for the solvents, water, ethanol, and tert-butyl alcohol. The importance of hydrogel equilibrium hydration in progesterone permeation is emphasized.