Biomaterial Database

Reduction of progesterone release rate through silicone membranes by plasma polymerization. 1977

K D Colter, and M Shen, and A T Bell

An investigation was performed to determine the effectiveness of thin plasma-polymerized films and CASING for controlling the flux of progesterone through poly-(dimethyl siloxane) membranes. It was concluded that up to 40-fold reductions in flux could be achieved with plasma-polymerized films. The principal factors affecting the extent of flux reduction were the nature of the monomer used (ethylene, ethane and tetrafluoroethylene), the film thickness, and the deposition conditions. CASING (Crosslinking by Activated Species of Inert Gases) of the poly-(dimethyl siloxane) membrane surface also proved effective in reducing the flux of progesterone through it.

UI	MeSH Term	Description	Entries
D011108	Polymers	Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).	Polymer
D011374	Progesterone	The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.	Pregnenedione,Progesterone, (13 alpha,17 alpha)-(+-)-Isomer,Progesterone, (17 alpha)-Isomer,Progesterone, (9 beta,10 alpha)-Isomer
D004058	Diffusion	The tendency of a gas or solute to pass from a point of higher pressure or concentration to a point of lower pressure or concentration and to distribute itself throughout the available space. Diffusion, especially FACILITATED DIFFUSION, is a major mechanism of BIOLOGICAL TRANSPORT.	Diffusions
D012828	Silicones	A broad family of synthetic organosiloxane polymers containing a repeating silicon-oxygen backbone with organic side groups attached via carbon-silicon bonds. Depending on their structure, they are classified as liquids, gels, and elastomers. (From Merck Index, 12th ed)	Silicone

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