-transparent.png){kind=logo}
Explants of 19- to 20-day fetal rat liver synthesize polypeptides biochemically and immunologically related to the well characterized somatomedin (insulin-like growth factor) BRL-MSA, multiplication-stimulating activity. Fetal MSA was purified from media conditioned by fetal liver explants by chromatography on Sephadex G-75 under acid conditions. Partially purified fetal MSA: 1) inhibited the binding of BRL-MSA to the MSA receptor of rat liver plasma membranes, to somatomedin-binding proteins from rat serum, and to rabbit anti-BRL-MSA serum; 2) had a molecular weight of 4,500 to 12,500 determined by polyacrylamide gel electrophoresis in sodium dodecyl sulfate; 3) stimulated the incorporation of [3H]thymidine into the DNA of chick embryo fibroblasts and induced cell multiplication; 4) stimulated glucose oxidation in rat adipocytes and weakly inhibited the binding of insulin to the insulin receptors of IM-9 lymphocytes; and 5) stimulated sulfate uptake in costal cartilage from hypophysectomized rats. These activities were associated with the same molecular species in fetal MSA preparations following disc acrylamide electrophoresis and co-migrated with active BRL-MSA peptides.
M M Rechler, and
H J Eisen, and
O Z Higa, and
P Nissley, and
A C Moses, and
E E Schilling, and
I Fennoy, and
C B Bruni, and
L S Phillips, and
K L Baird
January 1988,
Endocrinology,
M M Rechler, and
H J Eisen, and
O Z Higa, and
P Nissley, and
A C Moses, and
E E Schilling, and
I Fennoy, and
C B Bruni, and
L S Phillips, and
K L Baird
November 1986,
The Journal of biological chemistry,
M M Rechler, and
H J Eisen, and
O Z Higa, and
P Nissley, and
A C Moses, and
E E Schilling, and
I Fennoy, and
C B Bruni, and
L S Phillips, and
K L Baird
August 1996,
Endocrinology,
M M Rechler, and
H J Eisen, and
O Z Higa, and
P Nissley, and
A C Moses, and
E E Schilling, and
I Fennoy, and
C B Bruni, and
L S Phillips, and
K L Baird
January 1988,
Endocrinology,
M M Rechler, and
H J Eisen, and
O Z Higa, and
P Nissley, and
A C Moses, and
E E Schilling, and
I Fennoy, and
C B Bruni, and
L S Phillips, and
K L Baird
July 1989,
American journal of respiratory cell and molecular biology,
M M Rechler, and
H J Eisen, and
O Z Higa, and
P Nissley, and
A C Moses, and
E E Schilling, and
I Fennoy, and
C B Bruni, and
L S Phillips, and
K L Baird
September 1988,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
M M Rechler, and
H J Eisen, and
O Z Higa, and
P Nissley, and
A C Moses, and
E E Schilling, and
I Fennoy, and
C B Bruni, and
L S Phillips, and
K L Baird
March 1984,
Clinics in endocrinology and metabolism,
M M Rechler, and
H J Eisen, and
O Z Higa, and
P Nissley, and
A C Moses, and
E E Schilling, and
I Fennoy, and
C B Bruni, and
L S Phillips, and
K L Baird
August 2002,
Nihon rinsho. Japanese journal of clinical medicine,
M M Rechler, and
H J Eisen, and
O Z Higa, and
P Nissley, and
A C Moses, and
E E Schilling, and
I Fennoy, and
C B Bruni, and
L S Phillips, and
K L Baird
July 1986,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
M M Rechler, and
H J Eisen, and
O Z Higa, and
P Nissley, and
A C Moses, and
E E Schilling, and
I Fennoy, and
C B Bruni, and
L S Phillips, and
K L Baird
November 1985,
The Journal of endocrinology,
