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The urinary metabolites of flavanone in the rate were investigated using a gas chromatographic mass spectrometric method employing an OV-1 capillary column. Forty-three metabolites were detected and the most prominent of these were identified. The most common metabolic reactions were reduction of the keto group and hydroxylation at the 3- or 6-positions. Little hydroxylation occurred in ring B. The major metabolites were flavan-4 alpha-ol, trans-3-hydroxyflavan-4 beta-ol, 6-hydroxyflavanone and 6-hydroxyflavan-4 beta-ol. Gas chromatography analysis of underivatized flavanone metabolites, especially with stainless steel columns, results in the formation of dehydrated products including flavone, flav-3-ene and flavanone itself.
H Buset, and
R R Scheline
May 1995,
Xenobiotica; the fate of foreign compounds in biological systems,
H Buset, and
R R Scheline
January 1990,
Drug metabolism and disposition: the biological fate of chemicals,
H Buset, and
R R Scheline
December 1973,
The Biochemical journal,
H Buset, and
R R Scheline
March 1980,
Journal of toxicology and environmental health,
H Buset, and
R R Scheline
April 1993,
Xenobiotica; the fate of foreign compounds in biological systems,
H Buset, and
R R Scheline
February 1979,
Xenobiotica; the fate of foreign compounds in biological systems,
H Buset, and
R R Scheline
July 1978,
Xenobiotica; the fate of foreign compounds in biological systems,
H Buset, and
R R Scheline
October 1998,
Xenobiotica; the fate of foreign compounds in biological systems,
H Buset, and
R R Scheline
October 1986,
Biomedical & environmental mass spectrometry,
H Buset, and
R R Scheline
September 1976,
Helvetica chimica acta,
