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N-Acetyl-beta-D-hexosaminidase isolated from normal rat colon was compared to that obtained from a transplantable rat colonic carcinoma. Levels of total hexosaminidase from purified epithelial cells of normal colon were similar to those from purified malignant cells from the transplantable tumor. Cultured malignant cells had significantly higher levels of activity than did freshly purified tumor cells. Isoelectric focusing of hexosaminidase from normal rat colon indicated approximately equal amounts of A (pI 5.0 ) and B (pI 8.1) isoenzyme activity. The B isoenzyme (normal cell) was more stable to heat inactivation than was the A isoenzyme and had significantly higher activity at low pH's. In contrast, the B isoenzyme from the tumor was relatively unstable to heat and low pH.
M G Brattain, and
C Green, and
P M Kimball, and
M Marks, and
M Khaled
March 1977,
Cancer research,
M G Brattain, and
C Green, and
P M Kimball, and
M Marks, and
M Khaled
September 1979,
Cancer research,
M G Brattain, and
C Green, and
P M Kimball, and
M Marks, and
M Khaled
January 1999,
Acta biochimica Polonica,
M G Brattain, and
C Green, and
P M Kimball, and
M Marks, and
M Khaled
September 1992,
Clinical chemistry,
M G Brattain, and
C Green, and
P M Kimball, and
M Marks, and
M Khaled
January 1982,
Cancer,
M G Brattain, and
C Green, and
P M Kimball, and
M Marks, and
M Khaled
August 1995,
Scandinavian journal of clinical and laboratory investigation,
M G Brattain, and
C Green, and
P M Kimball, and
M Marks, and
M Khaled
April 1975,
Minerva pediatrica,
M G Brattain, and
C Green, and
P M Kimball, and
M Marks, and
M Khaled
January 1985,
Cellular and molecular biology,
M G Brattain, and
C Green, and
P M Kimball, and
M Marks, and
M Khaled
January 2001,
Advances in genetics,
M G Brattain, and
C Green, and
P M Kimball, and
M Marks, and
M Khaled
May 1984,
Bollettino della Societa italiana di biologia sperimentale,
