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1. Abnormalities in glycoprotein metabolism are believed to play a role in diabetic microangiopathy. We have therefore measured the urinary excretion of carbohydrate-containing materials in normal and diabetic subjects. 2. Diabetic subjects were found to excrete excessive quantities of such material, which may parallel the increases observed in plasma and structural glycoproteins found in previous studies. 3. Systemic administration of a synthetic derivative of vasicine, which is known to affect mucus glycoprotein, was shown to restore these elevated urinary concentrations seen in diabetic subjects to values close to normal, but his drug had no significant effect on urinary concentrations of such materials in normal subjects.
J R Clamp, and
M Hartog, and
J H Shelley
July 1977,
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J R Clamp, and
M Hartog, and
J H Shelley
June 1972,
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J R Clamp, and
M Hartog, and
J H Shelley
May 1979,
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J R Clamp, and
M Hartog, and
J H Shelley
January 1984,
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J R Clamp, and
M Hartog, and
J H Shelley
January 1926,
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J R Clamp, and
M Hartog, and
J H Shelley
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J R Clamp, and
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November 1984,
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J R Clamp, and
M Hartog, and
J H Shelley
October 1966,
Clinica chimica acta; international journal of clinical chemistry,
J R Clamp, and
M Hartog, and
J H Shelley
January 1980,
Diabetes care,
J R Clamp, and
M Hartog, and
J H Shelley
April 1966,
Biochimica et biophysica acta,
