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This study tested the hypothesis that the inhibitory action of secretin on gastrin-stimulated gastric acid and pepsin secretion is comprised in animals harboring intestinal stages of the parasite Trichinella spiralis. Pentagastrin-stimulated acid and pepsin secretion, and the influence of secretin on these processes, were measured in dogs prepared with gastric fistulas and Heidenhain pouches. Dogs were studied before and after infection with 10(4) T. spiralis larvae/kg body weight. Gastric secretion was stimulated by constant intravenous infusion of pentagastrin, 1 microgram/kg per hour. Exogenous secretin inhibited pentagastrin-stimulated acid and pepsin output from both the main stomach and Heidenhain pouch in infected as well as in the uninfected dogs. Identical inhibition was observed in uninfected dogs during duodenal infusion with HCl to release endogenous secretin. In contrast, duodenal stimulation with HCl did not inhibit acid and pepsin secretion in dogs tested during the 1st week following infection. Results support the conclusion that the regulatory effect of secretin on gastrin-stimulated gastric secretion is impaired during the early phase of infection, and is due to depressed synthesis or release of secretin from duodenal mucosa.
A B Dembinski, and
L R Johnson, and
G A Castro
November 1971,
Medizinische Klinik,
A B Dembinski, and
L R Johnson, and
G A Castro
January 1963,
Surgical forum,
A B Dembinski, and
L R Johnson, and
G A Castro
February 1964,
The American journal of digestive diseases,
A B Dembinski, and
L R Johnson, and
G A Castro
August 1984,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
A B Dembinski, and
L R Johnson, and
G A Castro
November 1972,
Horumon to rinsho. Clinical endocrinology,
A B Dembinski, and
L R Johnson, and
G A Castro
July 1968,
Experientia,
A B Dembinski, and
L R Johnson, and
G A Castro
September 1957,
The American journal of physiology,
A B Dembinski, and
L R Johnson, and
G A Castro
January 1998,
Digestion,
A B Dembinski, and
L R Johnson, and
G A Castro
March 1975,
Horumon to rinsho. Clinical endocrinology,
A B Dembinski, and
L R Johnson, and
G A Castro
September 1988,
Gastroenterology,
