-transparent.png){kind=logo}
BACKGROUND Gastric lipase secretion is stimulated by gastrin in plasma, but its regulation by secretin is unknown. METHODS In 7 normal persons we investigated the effect of exogenous secretin on the output of gastric lipase stimulated by intravenous gastrin-17. The gastric content was measured using a nasogastric tube for aspiration. The quantitative lipase secretion was measured by an enzyme-linked immunosorbant assay (ELISA) and the lipolytic activity by a kinetic assay. Plasma concentrations of secretin and gastrin were measured by radioimmunoassay. RESULTS Gastric lipase secretion (the quantity as well as the lipolytic activity) was significantly stimulated by gastrin. In response to secretin infusion, the lipolytic activity increased as acid secretion decreased. CONCLUSIONS Secretin in postprandial concentrations does not influence the quantitative gastric lipase secretion stimulated by gastrin, but it increases lipolytic activity due to inhibition of acid secretion.
O Olsen, and
M Wøjdemann, and
B Berner, and
G Christiansen, and
B Sternby
March 1975,
Horumon to rinsho. Clinical endocrinology,
O Olsen, and
M Wøjdemann, and
B Berner, and
G Christiansen, and
B Sternby
January 1963,
Surgical forum,
O Olsen, and
M Wøjdemann, and
B Berner, and
G Christiansen, and
B Sternby
December 1962,
Annals of surgery,
O Olsen, and
M Wøjdemann, and
B Berner, and
G Christiansen, and
B Sternby
February 1964,
The American journal of digestive diseases,
O Olsen, and
M Wøjdemann, and
B Berner, and
G Christiansen, and
B Sternby
August 1984,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
O Olsen, and
M Wøjdemann, and
B Berner, and
G Christiansen, and
B Sternby
November 1972,
Horumon to rinsho. Clinical endocrinology,
O Olsen, and
M Wøjdemann, and
B Berner, and
G Christiansen, and
B Sternby
January 1985,
American journal of surgery,
O Olsen, and
M Wøjdemann, and
B Berner, and
G Christiansen, and
B Sternby
July 1968,
Experientia,
O Olsen, and
M Wøjdemann, and
B Berner, and
G Christiansen, and
B Sternby
September 1957,
The American journal of physiology,
O Olsen, and
M Wøjdemann, and
B Berner, and
G Christiansen, and
B Sternby
September 1979,
The American journal of tropical medicine and hygiene,
