-transparent.png){kind=logo}
V79-379A cells growing in suspension culture were treated with N-methyl-N-nitrosourea at concentrations of 0.6 and 1.2 mM. After incubation for periods from 1 to 48 h DNA was isolated from the cells and the concentrations of 7-methylguanine, O6-methylguanine, 3-methyladenine and methyl phosphotriesters were determined. After correction for dilution resulting from DNA synthesis during the incubation it was found that no loss of O6-methylguanine or methylphosphotriesters occurred; 7-methylguanine disappeared with a half-life of 22 h and 3-methyladenine was detectable only immediately after the initial treatment. The results show that these cells eliminate 7-methylguanine and 3-methyladenine from DNA by a repair process but are unable to excise or repair O6-methylguanine or methyl phosphotriesters.
W Warren, and
A R Crathorn, and
K V Shooter
May 1979,
Cancer letters,
W Warren, and
A R Crathorn, and
K V Shooter
January 1981,
Carcinogenesis,
W Warren, and
A R Crathorn, and
K V Shooter
April 1980,
Bollettino della Societa italiana di biologia sperimentale,
W Warren, and
A R Crathorn, and
K V Shooter
July 1976,
Nucleic acids research,
W Warren, and
A R Crathorn, and
K V Shooter
February 1983,
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
W Warren, and
A R Crathorn, and
K V Shooter
May 1978,
Bollettino della Societa italiana di biologia sperimentale,
W Warren, and
A R Crathorn, and
K V Shooter
January 1985,
Mutation research,
W Warren, and
A R Crathorn, and
K V Shooter
November 1988,
Mutation research,
W Warren, and
A R Crathorn, and
K V Shooter
June 1983,
International journal of cancer,
W Warren, and
A R Crathorn, and
K V Shooter
September 1983,
Chemico-biological interactions,
