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Norepinephrine (NE) content in the brain slightly but significantly increased when gamma-oryzanol (100 mg/kg, s.c.) was given once daily for 1, 5 or 10 days, while NE in the gastric area was not affected. The turnover rate of brain NE tended to decrease with the administration of gamma-oryzanol. From the results, it is likely that successive doses of gamma-oryzanol increase brain NE by inhibiting degradation or release of NE.
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