-transparent.png){kind=logo}
Injections of sulfate ion in rats given the carcinogen N-hydroxy-2-acetylaminofluorene increased (i) the formation of 1-and 3-(methion-S-yl)-2-acetylaminofluorene bound to protein in the liver, (ii) the formation of fluorenyl derivatives bound to total protein, ribosomal RNA, and DNA in the liver, and (iii) the toxicity of the carcinogen. These data provide evidence that the highly reactive ester 2-acetylaminofluorene-N-sulfate, previously suggested as an ultimate reactive and carcinogenic metabolite of N-hydroxy-2-acetylaminofluorene, is formed in the rat liver in vivo.
Related Publications
J R DeBaun, and
J Y Smith, and
E C Miller, and
J A Miller
January 1978,
Experientia,
J R DeBaun, and
J Y Smith, and
E C Miller, and
J A Miller
February 1979,
Nucleic acids research,
J R DeBaun, and
J Y Smith, and
E C Miller, and
J A Miller
July 1973,
Canadian journal of biochemistry,
J R DeBaun, and
J Y Smith, and
E C Miller, and
J A Miller
May 1964,
The Journal of biological chemistry,
J R DeBaun, and
J Y Smith, and
E C Miller, and
J A Miller
November 1984,
Proceedings of the National Academy of Sciences of the United States of America,
J R DeBaun, and
J Y Smith, and
E C Miller, and
J A Miller
February 1985,
Carcinogenesis,
J R DeBaun, and
J Y Smith, and
E C Miller, and
J A Miller
March 1969,
Biochimica et biophysica acta,
J R DeBaun, and
J Y Smith, and
E C Miller, and
J A Miller
August 1983,
Carcinogenesis,
J R DeBaun, and
J Y Smith, and
E C Miller, and
J A Miller
June 1977,
Biochimica et biophysica acta,
J R DeBaun, and
J Y Smith, and
E C Miller, and
J A Miller
June 1971,
Biochimica et biophysica acta,
