-transparent.png){kind=logo}
Thymidine kinase, dTMP kinase, and DNA polymerase activities were determined in cell lines of AH hepatoma, L1210 leukemia, and Yoshida sarcoma that were sensitive and resistant to 5-fluorouracil (5-FU). It was found that the levels of these enzymes in tumor cells were not consistently related to the property of sensitivity to 5-FU. A marked difference was observed between sensitive and resistant cell lines of L1210 leukemia and Yoshida sarcoma in the uptake of labeled 5-FU into the acid-soluble, nucleotide, and RNA fractions, the rate of incorporation of 5-FU into these fractions being 3 to 5 times greater in sensitive tumor cells than in resistant tumor cells. The radioactivities in the acid-soluble fractions of AH44 (sensitive) and AH109A (resistant) were similar after incubation of these cells with labeled 5-FU in vitro. However, a smaller volume of ascites and lower cell number were observed in AH44 (sensitive)-bearing rats than in AH109A (resistant)-bearing rats. These in vivo results indicate that the 5-FU injected intraperitoneally was diluted by ascites more in AH109A (resistant)-bearing rats than in AH44 (sensitive)-bearing rats.
M Fukushima, and
K Ikenaka, and
T Shirasaka, and
S Fujii
February 1977,
The Journal of biological chemistry,
M Fukushima, and
K Ikenaka, and
T Shirasaka, and
S Fujii
February 1959,
Cancer research,
M Fukushima, and
K Ikenaka, and
T Shirasaka, and
S Fujii
January 1982,
Ukrainskii biokhimicheskii zhurnal (1978),
M Fukushima, and
K Ikenaka, and
T Shirasaka, and
S Fujii
February 1983,
Biulleten' eksperimental'noi biologii i meditsiny,
M Fukushima, and
K Ikenaka, and
T Shirasaka, and
S Fujii
May 1960,
Biochimica et biophysica acta,
M Fukushima, and
K Ikenaka, and
T Shirasaka, and
S Fujii
January 1996,
Oncology research,
M Fukushima, and
K Ikenaka, and
T Shirasaka, and
S Fujii
June 2001,
Japanese journal of cancer research : Gann,
M Fukushima, and
K Ikenaka, and
T Shirasaka, and
S Fujii
December 2020,
Oncology research,
M Fukushima, and
K Ikenaka, and
T Shirasaka, and
S Fujii
April 1984,
British journal of cancer,
M Fukushima, and
K Ikenaka, and
T Shirasaka, and
S Fujii
October 1989,
Applied and environmental microbiology,
