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The nucleolar DNA of Physarum polycephalum has been differentially labelled with 3H-thymidine and the structure of the nucleolar chromatin investigated by digestion with micrococcal nuclease. Nucleolar chromatin which had been labelled in G2 phase of the cell cycle and then digested before mitosis had an identical DNA repeat length to main band DNA (165 +/- 5 base pairs) but there was a definite indication that the rate of digestion was faster for nucleolar DNA than for main band DNA. Nucleolar chromatin which had been labelled in G2 and the label chased through mitosis into G2 phase of the next cycle showed an identical DNA repeat length to main band DNA and was also digested at the same rate. We conclude that nucleolar chromatin, at least 25 per cent of which is maximally transcriptionally active in G2, has a nucleosome-like structure.
M J Butler, and
K E Davies, and
I O Walker
November 1977,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
M J Butler, and
K E Davies, and
I O Walker
March 1976,
FEBS letters,
M J Butler, and
K E Davies, and
I O Walker
December 1976,
Nucleic acids research,
M J Butler, and
K E Davies, and
I O Walker
September 1979,
Toxicology and applied pharmacology,
M J Butler, and
K E Davies, and
I O Walker
June 1978,
FEBS letters,
M J Butler, and
K E Davies, and
I O Walker
July 1975,
Tsitologiia,
M J Butler, and
K E Davies, and
I O Walker
August 1987,
Journal of molecular biology,
M J Butler, and
K E Davies, and
I O Walker
March 1973,
Archives of biochemistry and biophysics,
M J Butler, and
K E Davies, and
I O Walker
January 1980,
Acta biochimica Polonica,
M J Butler, and
K E Davies, and
I O Walker
March 1977,
Biochimica et biophysica acta,
