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A series of rigid analogs of apomorphine lacking aromatic hydroxyl substitutents were evaluated for dopaminergic properties. Three compounds, N-methyl-N-propyl-2-aminotetralin (Me-Pr-2-AT), N-N-dipropyl-2-aminotetralin (Di-pr-2-AT) and N,N-dipropyl-2-aminoindane (Di-Pr-2-AI) induced emesis in dogs, contralateral circling in unilaterally lesioned rats, and inhibited prolactin secretion. The induced circling responses, however, were attenuated by prior treatment with alpha-methyl-p-tyrosine methyl ester (AMPTME) and the compounds were weak inhibitors of 3-H-dopamine binding in calf caudate homogenates. The possibility that these agents may be metabolically activated in vivo is discussed.
D B Rusterholz, and
J P Long, and
J R Flynn, and
J G Cannon, and
T Lee, and
J P Pease, and
J A Clemens, and
D T Wong, and
F P Bymaster
September 1976,
Research communications in chemical pathology and pharmacology,
D B Rusterholz, and
J P Long, and
J R Flynn, and
J G Cannon, and
T Lee, and
J P Pease, and
J A Clemens, and
D T Wong, and
F P Bymaster
January 1978,
European journal of pharmacology,
D B Rusterholz, and
J P Long, and
J R Flynn, and
J G Cannon, and
T Lee, and
J P Pease, and
J A Clemens, and
D T Wong, and
F P Bymaster
January 2006,
Molecular pharmaceutics,
D B Rusterholz, and
J P Long, and
J R Flynn, and
J G Cannon, and
T Lee, and
J P Pease, and
J A Clemens, and
D T Wong, and
F P Bymaster
March 1986,
The Journal of pharmacology and experimental therapeutics,
D B Rusterholz, and
J P Long, and
J R Flynn, and
J G Cannon, and
T Lee, and
J P Pease, and
J A Clemens, and
D T Wong, and
F P Bymaster
January 1974,
Advances in neurology,
D B Rusterholz, and
J P Long, and
J R Flynn, and
J G Cannon, and
T Lee, and
J P Pease, and
J A Clemens, and
D T Wong, and
F P Bymaster
June 1989,
Lancet (London, England),
D B Rusterholz, and
J P Long, and
J R Flynn, and
J G Cannon, and
T Lee, and
J P Pease, and
J A Clemens, and
D T Wong, and
F P Bymaster
February 1974,
Journal of medicinal chemistry,
D B Rusterholz, and
J P Long, and
J R Flynn, and
J G Cannon, and
T Lee, and
J P Pease, and
J A Clemens, and
D T Wong, and
F P Bymaster
November 1978,
European journal of pharmacology,
D B Rusterholz, and
J P Long, and
J R Flynn, and
J G Cannon, and
T Lee, and
J P Pease, and
J A Clemens, and
D T Wong, and
F P Bymaster
September 1982,
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
D B Rusterholz, and
J P Long, and
J R Flynn, and
J G Cannon, and
T Lee, and
J P Pease, and
J A Clemens, and
D T Wong, and
F P Bymaster
January 2000,
Neurology,
