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The dopaminergic activity of ten apomorphine analogs was studied in rats lesioned unilaterally with 6-hydroxydopamine in the nigro-striatal system. Of these ten compounds, N,N-dimethyl-5,6-dihydroxy-2-amino-tetralin (M-7), N-methyl-5,6-dihydroxy-2-aminotetralin (M-8) and N,N-dimethyl-4,5-dihydroxy-2-aminoindan (DDAI) exhibited potent dopaminergic stimulant activity by causing the rat to turn to the unoperated side. The turning behavior of apomorphine, M-7, DDAI and d-amphetamine were antagonized by haloperidol. M-7 and DDAI also induced pecking in pigeons and their effects were also blocked by haloperidol. It is concluded that M-7, M-8 and DDAI are direct acting central dopaminergic agents.
H C Cheng, and
J P Long, and
L S Van Orden, and
J G Cannon, and
J P O'Donnell
April 1979,
European journal of pharmacology,
H C Cheng, and
J P Long, and
L S Van Orden, and
J G Cannon, and
J P O'Donnell
January 1974,
Advances in neurology,
H C Cheng, and
J P Long, and
L S Van Orden, and
J G Cannon, and
J P O'Donnell
December 1985,
Pharmacological research communications,
H C Cheng, and
J P Long, and
L S Van Orden, and
J G Cannon, and
J P O'Donnell
January 2006,
Molecular pharmaceutics,
H C Cheng, and
J P Long, and
L S Van Orden, and
J G Cannon, and
J P O'Donnell
June 1989,
Lancet (London, England),
H C Cheng, and
J P Long, and
L S Van Orden, and
J G Cannon, and
J P O'Donnell
December 1980,
Die Naturwissenschaften,
H C Cheng, and
J P Long, and
L S Van Orden, and
J G Cannon, and
J P O'Donnell
November 1983,
Neuropharmacology,
H C Cheng, and
J P Long, and
L S Van Orden, and
J G Cannon, and
J P O'Donnell
January 2000,
European journal of pharmacology,
H C Cheng, and
J P Long, and
L S Van Orden, and
J G Cannon, and
J P O'Donnell
June 1980,
European journal of pharmacology,
H C Cheng, and
J P Long, and
L S Van Orden, and
J G Cannon, and
J P O'Donnell
July 2002,
Behavioural brain research,
