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The determination of 2-(2-hydroxyethoxy)-ethyl-N-(a,a,a-trifluoro-m-tolyl)-anthranilate (etofenamate, active principle of Rheumon gel) following its isolation from biological material is reported. Depending on the method of extraction etofenamate, free and alkali-labile conjugated flufenamic acid, total conjugates or the sum of CF3-containing compounds (sum of metabolites) are isolated. Separation is achieved by TLC, quantitative determination is made by degradation to flufenamic acid and fluorimetric measurement in CCl4/trichloracetic acid at 372/445 nm. Etofenamate can be identified by TLC, derivatisation, UV- and fluorescence spectroscopy and differentiated from its metabolites. It is demonstrated that etofenamate is the main component of fenamates in inflamed tissue.
H D Dell, and
J Fiedler, and
B Wäsche
December 1988,
Clinical chemistry,
H D Dell, and
J Fiedler, and
B Wäsche
August 1973,
Archiv fur Toxikologie,
H D Dell, and
J Fiedler, and
B Wäsche
October 1981,
Casopis lekaru ceskych,
H D Dell, and
J Fiedler, and
B Wäsche
September 1975,
Journal of chromatography,
H D Dell, and
J Fiedler, and
B Wäsche
January 1977,
Arzneimittel-Forschung,
H D Dell, and
J Fiedler, and
B Wäsche
October 1976,
Archives of toxicology,
H D Dell, and
J Fiedler, and
B Wäsche
January 1974,
Archives of toxicology,
H D Dell, and
J Fiedler, and
B Wäsche
January 1976,
Arzneimittel-Forschung,
H D Dell, and
J Fiedler, and
B Wäsche
January 1977,
Arzneimittel-Forschung,
H D Dell, and
J Fiedler, and
B Wäsche
March 1976,
Kokyu to junkan. Respiration & circulation,
