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As free amino acids in the brain have a role in the development of physical dependence on and tolerance to morphine, and in the mechanism of action of some drugs, the effects of aspartic acid which antagonizes some effects of the single dose of morphine were studied during the development of the physical dependence on morphine and after the withdrawal of morphine. 108 rats were given morphine and aspartic acid in different combinations in drinking water for 30 days. Every tenth day the dose of morphine was increased: At the end of this period some of them in each group continued or began to receive aspartic acid depending on the experimental conditions after the withdrawal of morphine. During the experiments body weight, spontaneous motor activity and analgesic threshold were determined. Aspartic acid prevented the alterations induced by morphine during the development of physical dependence and tolerance. Furthermore the rats that received aspartic acid after the withdrawal showed no body weight loss.
H Koyuncuoglu, and
H Sagduyu, and
M Güngör, and
L Eroglu, and
E Genç
October 1977,
Psychopharmacology,
H Koyuncuoglu, and
H Sagduyu, and
M Güngör, and
L Eroglu, and
E Genç
October 1978,
British journal of pharmacology,
H Koyuncuoglu, and
H Sagduyu, and
M Güngör, and
L Eroglu, and
E Genç
January 1979,
Polish journal of pharmacology and pharmacy,
H Koyuncuoglu, and
H Sagduyu, and
M Güngör, and
L Eroglu, and
E Genç
August 1976,
European journal of pharmacology,
H Koyuncuoglu, and
H Sagduyu, and
M Güngör, and
L Eroglu, and
E Genç
November 2004,
Bulletin of experimental biology and medicine,
H Koyuncuoglu, and
H Sagduyu, and
M Güngör, and
L Eroglu, and
E Genç
June 1971,
Japanese journal of pharmacology,
H Koyuncuoglu, and
H Sagduyu, and
M Güngör, and
L Eroglu, and
E Genç
January 1982,
Clinical and experimental pharmacology & physiology,
H Koyuncuoglu, and
H Sagduyu, and
M Güngör, and
L Eroglu, and
E Genç
September 1975,
Life sciences,
H Koyuncuoglu, and
H Sagduyu, and
M Güngör, and
L Eroglu, and
E Genç
May 1963,
Psychopharmacologia,
H Koyuncuoglu, and
H Sagduyu, and
M Güngör, and
L Eroglu, and
E Genç
April 1980,
Pharmacology, biochemistry, and behavior,
