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After intravenous and oral application of 25 mg 6-(sulfanilamido)-2,4-dimethyl-pyrimidine (sulfasomidin)/kg body-weight to 29 newborns, 8 infants and 9 older children the completeness and rate of absorption were determined. Sulfasomidine was completely absorbed in newborns (mean value 95.7%) as well as in older children (mean value 94.4%). Concerning the rate of absorption there were age-dependent differences. Using the Bateman function for the kinetic model of intestinal absorption the rate constant of invasion k1 was significantly lower in the first week of life compared to that in older children. In agreement with these data the time tmax of the maximum serum concentration was significantly prolonged in newborns compared to that of older children.
G Heimann, and
J Mensah-Kordieh, and
B Roth, and
E Gladtke
January 1977,
Arzneimittel-Forschung,
G Heimann, and
J Mensah-Kordieh, and
B Roth, and
E Gladtke
January 1978,
Arzneimittel-Forschung,
G Heimann, and
J Mensah-Kordieh, and
B Roth, and
E Gladtke
January 1981,
Shika gakuho. Dental science reports,
G Heimann, and
J Mensah-Kordieh, and
B Roth, and
E Gladtke
January 1979,
Zeitschrift fur Alternsforschung,
G Heimann, and
J Mensah-Kordieh, and
B Roth, and
E Gladtke
January 1978,
Klinische Wochenschrift,
G Heimann, and
J Mensah-Kordieh, and
B Roth, and
E Gladtke
January 1977,
Zeitschrift fur Alternsforschung,
G Heimann, and
J Mensah-Kordieh, and
B Roth, and
E Gladtke
July 1990,
Biulleten' eksperimental'noi biologii i meditsiny,
G Heimann, and
J Mensah-Kordieh, and
B Roth, and
E Gladtke
February 1982,
Leber, Magen, Darm,
G Heimann, and
J Mensah-Kordieh, and
B Roth, and
E Gladtke
January 1978,
Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina,
G Heimann, and
J Mensah-Kordieh, and
B Roth, and
E Gladtke
March 1977,
Aktuelle Gerontologie,
