-transparent.png){kind=logo}
1. The qualitative and quantitative aspects of the urinary elimination of orally administered 4-methoxy[14C]amphetamine have been examined in the rat and guinea-pig and in three volunteer human subjects, to determine interspecies and interindividual variations in disposition of the drug. 2. Both rat and guinea-pig excreted 70--80% of the administered dose(6 mg/kg) in the urine within 24 h, mainly as metabolites. 3. In the guinea-pig, the drug was metabolized by O-demethylation to give 4-hydroxyamphetamine, which was excreted free (4% dose) and conjugated (73%). No other metabolite was detected. 4. The rat metabolizes the drug both by O-dealkylation and by side-chain oxidation, the products being 4-hydroxyamphetamine (5% of dose free and 60% conjugated) and 1-(4'-methoxyphenyl)propan-2-one oxime (5% dose, free and conjugated). 5. In man the drug (dose 5 mg) is metabolized by O-demethylation and by side-chain oxidation. Marked intersubject variations were observed both in the array and quantitative aspects of metabolite excretion. Two subjects excreted mainly 4-hydroxyamphetamine (free and conjugated) together with smaller amounts of 1-(4'-methoxyphenyl)propan-2-one oxime and 4-hydroxynorephedrine. The third subject, however, who was previously known to exhibit a genetically determined defect in drug oxidation, was defective in O-dealkylation of 4-methoxyamphetamine, and the main excretion products were the unchanged drug together with products of side-chain oxidation, namely, 1-(4'-methoxyphenyl)propan-2-one oxime, 1-(4'-methoxyphenyl)propan-2-one and 4-methoxybenzoic acid. 6. Inter-individual differences in oxidative O-demethylation of the drug are discussed in relation to current theories on the aetiology of schizophrenia and reported fatalities arising from abuse of the drug.
I Kitchen, and
J Tremblay, and
J André, and
L G Dring, and
J R Idle, and
R L Smith, and
R T Williams
January 1989,
Pharmacology & therapeutics,
I Kitchen, and
J Tremblay, and
J André, and
L G Dring, and
J R Idle, and
R L Smith, and
R T Williams
October 1985,
American journal of obstetrics and gynecology,
I Kitchen, and
J Tremblay, and
J André, and
L G Dring, and
J R Idle, and
R L Smith, and
R T Williams
January 2015,
Applied and environmental microbiology,
I Kitchen, and
J Tremblay, and
J André, and
L G Dring, and
J R Idle, and
R L Smith, and
R T Williams
September 2014,
Archives of toxicology,
I Kitchen, and
J Tremblay, and
J André, and
L G Dring, and
J R Idle, and
R L Smith, and
R T Williams
January 2016,
Current drug metabolism,
I Kitchen, and
J Tremblay, and
J André, and
L G Dring, and
J R Idle, and
R L Smith, and
R T Williams
November 1992,
Environmental health perspectives,
I Kitchen, and
J Tremblay, and
J André, and
L G Dring, and
J R Idle, and
R L Smith, and
R T Williams
January 1984,
IARC scientific publications,
I Kitchen, and
J Tremblay, and
J André, and
L G Dring, and
J R Idle, and
R L Smith, and
R T Williams
April 2000,
Journal of clinical psychopharmacology,
I Kitchen, and
J Tremblay, and
J André, and
L G Dring, and
J R Idle, and
R L Smith, and
R T Williams
May 2013,
Xenobiotica; the fate of foreign compounds in biological systems,
I Kitchen, and
J Tremblay, and
J André, and
L G Dring, and
J R Idle, and
R L Smith, and
R T Williams
August 2003,
Neuroreport,
