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Experimental infection of the nude (nu/nu) mouse with the intestinal flagellate, Spironucleus (Hexamita) muris, was used as animal model for immunologic studies and for the testing of protozoa cides. The fecal discharge of cysts was shown to correlate with the immune status of the host. It was dependent on the strain, presence of the thymus (nu/nu and nu/+), and age (immunologic maturity). Four protozoacides (dimetridazole, metronidazole, tinidazole, and chlormethoxyacridylamino-diethylaminopropanol-dihydrochloride) were tested in infected mice. All lowered or suppressed the fecal discharge of cysts during treatment; however, the cysts reappeared in the feces when treatment, lasting 1-3 weeks, was terminated. It was concluded that experimental infection of the nude mouse with S muris was an excellent model for immunologic and pharmacologic studies.
I Kunstyr, and
E Ammerpohl, and
B Meyer
July 1979,
Laboratory animals,
I Kunstyr, and
E Ammerpohl, and
B Meyer
January 1976,
Postepy higieny i medycyny doswiadczalnej,
I Kunstyr, and
E Ammerpohl, and
B Meyer
July 1977,
Science (New York, N.Y.),
I Kunstyr, and
E Ammerpohl, and
B Meyer
January 1988,
Nihon Rai Gakkai zasshi,
I Kunstyr, and
E Ammerpohl, and
B Meyer
May 1981,
The Journal of infectious diseases,
I Kunstyr, and
E Ammerpohl, and
B Meyer
March 2002,
Annals of the New York Academy of Sciences,
I Kunstyr, and
E Ammerpohl, and
B Meyer
February 1978,
Laboratory animal science,
I Kunstyr, and
E Ammerpohl, and
B Meyer
April 1975,
Research communications in chemical pathology and pharmacology,
I Kunstyr, and
E Ammerpohl, and
B Meyer
January 1981,
Journal of endocrinological investigation,
I Kunstyr, and
E Ammerpohl, and
B Meyer
January 1984,
Deutsche Zeitschrift fur Mund-, Kiefer- und Gesichts-Chirurgie,
