Biomaterial Database

[Pharmacokinetic studies of "Pharmachem" tylosin with healthy and infectious epididymitis-affected rams]. 1977

K Bakurdzhiev, and B Donev

The retention in blood and the excretion with semen were followed up of tylosin-base, product of the State Economic Corporation "Pharmachim" (People's Republic of Bulgaria). It was found that at muscular application (12 mg/kg) the preparation is resorbed at the site of injection and is retained at a therapeutic level concentration in the blood of rams in the course of 24 to 26 hours. Tylosin gains access to the testes and is excreted with the semen at the same rate as in infectious epididymitis-intact rams. No correlation has been observed between the blood level of tylosin and the content of tylosin in the spermal plasma. The single treatment of rams with tylosin at the dosing cited above is not able to arrest the excretion of Brucella organisms with the semen, and does not improve its morphologic composition.

UI	MeSH Term	Description	Entries
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D007933	Leucomycins	An antibiotic complex produced by Streptomyces kitasatoensis. The complex consists of a mixture of at least eight biologically active components, A1 and A3 to A9. Leucomycins have both antibacterial and antimycoplasmal activities.
D008297	Male		Males
D002002	Brucella	A genus of gram-negative, aerobic bacteria that causes BRUCELLOSIS. Its cells are nonmotile coccobacilli and are animal parasites and pathogens. The bacterium is transmissible to humans through contact with infected dairy products or tissue.
D002031	Bulgaria	A country in Southeastern Europe, bordering the Black Sea, between Romania and Turkey. The capital is Sofia.
D004341	Drug Evaluation	Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.	Evaluation Studies, Drug,Drug Evaluation Studies,Drug Evaluation Study,Drug Evaluations,Evaluation Study, Drug,Evaluation, Drug,Evaluations, Drug,Studies, Drug Evaluation,Study, Drug Evaluation
D004823	Epididymitis	Inflammation of the EPIDIDYMIS. Its clinical features include enlarged epididymis, a swollen SCROTUM; PAIN; PYURIA; and FEVER. It is usually related to infections in the URINARY TRACT, which likely spread to the EPIDIDYMIS through either the VAS DEFERENS or the lymphatics of the SPERMATIC CORD.	Epididymitides
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000900	Anti-Bacterial Agents	Substances that inhibit the growth or reproduction of BACTERIA.	Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D001702	Biopharmaceutics	The study of the physical and chemical properties of a drug and its dosage form as related to the onset, duration, and intensity of its action.	Pharmaceutics,Pharmaceutic