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The use of Gurdon's Xenopus oocyte translation system has allowed the production of neurotransmitter receptors in a foreign cell membrane, following the translation of microinjected mRNA isolated from various sources. This very accessible and relatively simple preparation permits the study of the requirements for receptor-ionophore function, assembly and membrane integration. This analysis is presently feasible for the peripheral nicotinic acetylcholine receptor, the chick brain gamma-aminobutyrate (GABA) receptor and the rat brain serotonin receptor. We now report the novel and successful expression of the GABA, glycine, glutamate and related acidic amino acid receptors of mammalian brain, and show that they exhibit pharmacologically separate identities when their mRNAs are processed in the amphibian oocyte.
K M Houamed, and
G Bilbe, and
T G Smart, and
A Constanti, and
D A Brown, and
E A Barnard, and
B M Richards
September 1987,
Brain research,
K M Houamed, and
G Bilbe, and
T G Smart, and
A Constanti, and
D A Brown, and
E A Barnard, and
B M Richards
March 1994,
Brain research. Molecular brain research,
K M Houamed, and
G Bilbe, and
T G Smart, and
A Constanti, and
D A Brown, and
E A Barnard, and
B M Richards
July 1986,
Brain research,
K M Houamed, and
G Bilbe, and
T G Smart, and
A Constanti, and
D A Brown, and
E A Barnard, and
B M Richards
June 1991,
Neuroscience research,
K M Houamed, and
G Bilbe, and
T G Smart, and
A Constanti, and
D A Brown, and
E A Barnard, and
B M Richards
August 1992,
Japanese journal of pharmacology,
K M Houamed, and
G Bilbe, and
T G Smart, and
A Constanti, and
D A Brown, and
E A Barnard, and
B M Richards
September 1990,
Biochemical and biophysical research communications,
K M Houamed, and
G Bilbe, and
T G Smart, and
A Constanti, and
D A Brown, and
E A Barnard, and
B M Richards
March 1990,
FEBS letters,
K M Houamed, and
G Bilbe, and
T G Smart, and
A Constanti, and
D A Brown, and
E A Barnard, and
B M Richards
November 1996,
Journal of neurochemistry,
K M Houamed, and
G Bilbe, and
T G Smart, and
A Constanti, and
D A Brown, and
E A Barnard, and
B M Richards
September 1983,
Neuroscience letters,
K M Houamed, and
G Bilbe, and
T G Smart, and
A Constanti, and
D A Brown, and
E A Barnard, and
B M Richards
December 1989,
FEBS letters,
