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The ascites fluids from patients with hepatoma or ovarian tumor and the pleural fluid from patients with malignant lymphoma elicited fatty acid release in slices of rat adipose tissue in vitro. The lipolytic factor, named toxohormone-L, was isolated from the ascites fluid of patients with hepatoma. The isolated preparation gave a single band on both disc gel electrophoresis and sodium dodecyl sulfate (SDS)-acrylamide gel electrophoresis in the presence of beta-mercaptoethanol. Its molecular weight was determined to be 70,000-75,000 and 65,200 by SDS-acrylamide gel electrophoresis and analytical ultracentrifugation respectively. Injection of toxohormone-L into the lateral ventricle of rats significantly suppressed food and water intakes. There was at least a 5-hr delay between its injection and the appearance of its suppressive effect.
H Masuno, and
H Yoshimura, and
N Ogawa, and
H Okuda
August 1992,
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H Masuno, and
H Yoshimura, and
N Ogawa, and
H Okuda
January 1981,
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H Masuno, and
H Yoshimura, and
N Ogawa, and
H Okuda
July 1978,
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H Masuno, and
H Yoshimura, and
N Ogawa, and
H Okuda
July 1978,
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H Masuno, and
H Yoshimura, and
N Ogawa, and
H Okuda
August 1979,
Agents and actions,
H Masuno, and
H Yoshimura, and
N Ogawa, and
H Okuda
July 1988,
Cancer research,
H Masuno, and
H Yoshimura, and
N Ogawa, and
H Okuda
June 1971,
The Kumamoto medical journal,
H Masuno, and
H Yoshimura, and
N Ogawa, and
H Okuda
December 1957,
The Tohoku journal of experimental medicine,
H Masuno, and
H Yoshimura, and
N Ogawa, and
H Okuda
September 1954,
Gan,
H Masuno, and
H Yoshimura, and
N Ogawa, and
H Okuda
January 1969,
Biokhimiia (Moscow, Russia),
