-transparent.png){kind=logo}
Since atrial natriuretic factor (ANF) blocks the contractile effect of angiotensin II on vascular strips, we investigated the action of the synthetic 48-73 ANF (previously called 8-33 ANF) on another target tissue of angiotensin II, the adrenal glomerulosa. ANF did not affect basal aldosterone output by isolated rat adrenal glomerulosa cells. ANF inhibited aldosterone secretion stimulated by 10(-8)M angiotensin II with an IC50 of 1.3 X 10(-9)M. Aldosterone secretion stimulated by 2.9 X 10(-10)M ACTH and by 15 mM potassium was similarly inhibited by ANF. In vivo, ANF blocked the effect of angiotensin II infused iv on aldosterone secretion in conscious unrestrained rats. We conclude that ANF is a non-selective inhibitor of stimulated aldosterone output.
L Chartier, and
E Schiffrin, and
G Thibault, and
R Garcia
January 1988,
European journal of clinical pharmacology,
L Chartier, and
E Schiffrin, and
G Thibault, and
R Garcia
January 1988,
Life sciences,
L Chartier, and
E Schiffrin, and
G Thibault, and
R Garcia
October 1989,
Brain research,
L Chartier, and
E Schiffrin, and
G Thibault, and
R Garcia
January 1984,
Hypertension (Dallas, Tex. : 1979),
L Chartier, and
E Schiffrin, and
G Thibault, and
R Garcia
April 1988,
Endocrinology,
L Chartier, and
E Schiffrin, and
G Thibault, and
R Garcia
February 1989,
Biochemical and biophysical research communications,
L Chartier, and
E Schiffrin, and
G Thibault, and
R Garcia
February 1978,
Journal of steroid biochemistry,
L Chartier, and
E Schiffrin, and
G Thibault, and
R Garcia
January 1987,
Endocrinology,
L Chartier, and
E Schiffrin, and
G Thibault, and
R Garcia
May 1986,
Clinical science (London, England : 1979),
L Chartier, and
E Schiffrin, and
G Thibault, and
R Garcia
January 1986,
Klinische Wochenschrift,
