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Human T-cell leukaemia virus type III (HTLV-III) is suspected of having a key role in the pathogenesis of acquired immune deficiency syndrome (AIDS). Epidemiological data suggest that AIDS is transmitted by an infectious agent through intimate contact with body secretions, blood or blood products. To maintain haemostasis, many haemophiliac patients depend on commercially prepared clotting concentrates made from large multi-donor plasma pools and are thus at increased risk of developing the disease. We report here that, using indirect membrane immunofluorescence and radioimmunoprecipitation with SDS-polyacrylamide gel electrophoresis, we have detected antibodies to HTLV-III in 30 of 47 (64%) asymptomatic haemophiliacs and in all of three haemophiliacs who either had or soon developed AIDS. Of 34 samples drawn before 1984, 18 (53%) were antibody-positive, whereas of 16 samples drawn during 1984, 15 (94%) were positive (P less than or equal to 0.002). These data suggest that exposure to HTLV-III antigens is widespread among asymptomatic haemophiliacs.
L W Kitchen, and
F Barin, and
J L Sullivan, and
M F McLane, and
D B Brettler, and
P H Levine, and
M Essex
January 1986,
Vox sanguinis,
L W Kitchen, and
F Barin, and
J L Sullivan, and
M F McLane, and
D B Brettler, and
P H Levine, and
M Essex
September 1983,
Lancet (London, England),
L W Kitchen, and
F Barin, and
J L Sullivan, and
M F McLane, and
D B Brettler, and
P H Levine, and
M Essex
December 1985,
Blood,
L W Kitchen, and
F Barin, and
J L Sullivan, and
M F McLane, and
D B Brettler, and
P H Levine, and
M Essex
January 1986,
Nature,
L W Kitchen, and
F Barin, and
J L Sullivan, and
M F McLane, and
D B Brettler, and
P H Levine, and
M Essex
September 1984,
The Medical journal of Australia,
L W Kitchen, and
F Barin, and
J L Sullivan, and
M F McLane, and
D B Brettler, and
P H Levine, and
M Essex
January 1985,
Vox sanguinis,
L W Kitchen, and
F Barin, and
J L Sullivan, and
M F McLane, and
D B Brettler, and
P H Levine, and
M Essex
October 2014,
The Lancet. Oncology,
L W Kitchen, and
F Barin, and
J L Sullivan, and
M F McLane, and
D B Brettler, and
P H Levine, and
M Essex
June 1986,
Journal of clinical microbiology,
L W Kitchen, and
F Barin, and
J L Sullivan, and
M F McLane, and
D B Brettler, and
P H Levine, and
M Essex
August 1985,
Lancet (London, England),
L W Kitchen, and
F Barin, and
J L Sullivan, and
M F McLane, and
D B Brettler, and
P H Levine, and
M Essex
July 1985,
British journal of haematology,
