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Inoculation of rabbits and mice with a vaccinia-rabies glycoprotein recombinant (V-RG) virus resulted in rapid induction of high concentrations of rabies virus-neutralizing antibodies and protection from severe intracerebral challenge with several strains of rabies virus. Protection from virus challenge also was achieved against the rabies-related Duvenhage virus but not against the Mokola virus. Effective immunization by V-RG depended on the expression of a rabies glycoprotein that registered proline rather than leucine as the eighth amino acid from its NH2 terminus (V-RGpro8). A minimum dose required for effective immunization of mice was 10(4) plaque-forming units of V-RGpro8 virus. beta-propiolactone-inactivated preparations of V-RGpro8 virus also induced high levels of rabies virus-neutralizing antibody and protected mice against intracerebral challenge with street rabies virus. V-RGpro8 virus was highly effective in priming mice to generate a secondary rabies virus-specific cytotoxic T-lymphocyte response following culture of lymphocytes with either ERA or PM strains of rabies virus.
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R I Macfarlan, and
K J Reagan, and
B Dietzschold, and
P J Curtis, and
W H Wunner, and
M P Kieny, and
R Lathe, and
J P Lecocq, and
M Mackett
January 1984,
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T J Wiktor, and
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K J Reagan, and
B Dietzschold, and
P J Curtis, and
W H Wunner, and
M P Kieny, and
R Lathe, and
J P Lecocq, and
M Mackett
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T J Wiktor, and
R I Macfarlan, and
K J Reagan, and
B Dietzschold, and
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M Mackett
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M Mackett
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T J Wiktor, and
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