BIOMAT Database Logo BIOMAT Database Logo

Nucleotide sequence of a human gene coding for a polypeptide hormone. 1977

P H Seeburg, and J Shine, and J A Martial, and A Ullrich, and H M Goodman, and J D Baxter

In summary, a general approach is presented to purify and sequence DNA fragments of a specific gene starting with a heterogeneous mixture of mRNAs. The methodology has been applied to the determination of the DNA sequence of a portion of the gene for human chorionic somatomammotropin. Most of the possible translation codons of the genetic code were found to be used. Some selectivity in the codon choices was found, and this may be important for RNA or gene regulation or structure. The stop codon UAG was found and a second stop codon in the same reading frame was found nine bases farther down. Finally, a "palindrome" sequence was detected in the 3' noncoding region.

UI MeSH Term Description Entries
D010928 Placental Lactogen A polypeptide hormone of approximately 25 kDa that is produced by the SYNCYTIOTROPHOBLASTS of the PLACENTA, also known as chorionic somatomammotropin. It has both GROWTH HORMONE and PROLACTIN activities on growth, lactation, and luteal steroid production. In women, placental lactogen secretion begins soon after implantation and increases to 1 g or more a day in late pregnancy. Placental lactogen is also an insulin antagonist. Choriomammotropin,Chorionic Somatomammotropin, Human,Human Placental Lactogen,Lactogen Hormone, Placental,Mammotropic Hormone, Placental,Somatomammotropin, Chorionic,Choriomammotrophin,HCS (Human Chorionic Somatomammotropin),HPL (Human Placental Lactogen),PAPP-D,Placental Luteotropin,Pregnancy-Associated Plasma Protein D,Chorionic Somatomammotropin,Human Chorionic Somatomammotropin,Lactogen, Placental,Luteotropin, Placental,Placental Lactogen, Human,Placental Mammotropic Hormone,Pregnancy Associated Plasma Protein D
D003062 Codon A set of three nucleotides in a protein coding sequence that specifies individual amino acids or a termination signal (CODON, TERMINATOR). Most codons are universal, but some organisms do not produce the transfer RNAs (RNA, TRANSFER) complementary to all codons. These codons are referred to as unassigned codons (CODONS, NONSENSE). Codon, Sense,Sense Codon,Codons,Codons, Sense,Sense Codons
D003854 Deoxyribonucleotides A purine or pyrimidine base bonded to a DEOXYRIBOSE containing a bond to a phosphate group. Deoxyribonucleotide
D004247 DNA A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine). DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA
D005796 Genes A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms. Cistron,Gene,Genetic Materials,Cistrons,Genetic Material,Material, Genetic,Materials, Genetic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001483 Base Sequence The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence. DNA Sequence,Nucleotide Sequence,RNA Sequence,DNA Sequences,Base Sequences,Nucleotide Sequences,RNA Sequences,Sequence, Base,Sequence, DNA,Sequence, Nucleotide,Sequence, RNA,Sequences, Base,Sequences, DNA,Sequences, Nucleotide,Sequences, RNA
D012333 RNA, Messenger RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm. Messenger RNA,Messenger RNA, Polyadenylated,Poly(A) Tail,Poly(A)+ RNA,Poly(A)+ mRNA,RNA, Messenger, Polyadenylated,RNA, Polyadenylated,mRNA,mRNA, Non-Polyadenylated,mRNA, Polyadenylated,Non-Polyadenylated mRNA,Poly(A) RNA,Polyadenylated mRNA,Non Polyadenylated mRNA,Polyadenylated Messenger RNA,Polyadenylated RNA,RNA, Polyadenylated Messenger,mRNA, Non Polyadenylated

Related Publications

P H Seeburg, and J Shine, and J A Martial, and A Ullrich, and H M Goodman, and J D Baxter
The nucleotide sequence of a gene coding for human serine tRNA.
December 1987, Nucleic acids research,
P H Seeburg, and J Shine, and J A Martial, and A Ullrich, and H M Goodman, and J D Baxter
Nucleotide sequence of the human parathyroid hormone gene.
April 1983, Proceedings of the National Academy of Sciences of the United States of America,
P H Seeburg, and J Shine, and J A Martial, and A Ullrich, and H M Goodman, and J D Baxter
The complete nucleotide sequence of the gene coding for the human aldolase C.
May 1988, Nucleic acids research,
P H Seeburg, and J Shine, and J A Martial, and A Ullrich, and H M Goodman, and J D Baxter
Nucleotide sequence of a cyanobacterial nifH gene coding for nitrogenase reductase.
November 1980, Proceedings of the National Academy of Sciences of the United States of America,
P H Seeburg, and J Shine, and J A Martial, and A Ullrich, and H M Goodman, and J D Baxter
Cloning and nucleotide sequence of DNA coding for bovine preproparathyroid hormone.
October 1979, Proceedings of the National Academy of Sciences of the United States of America,
P H Seeburg, and J Shine, and J A Martial, and A Ullrich, and H M Goodman, and J D Baxter
The nucleotide sequence of the polypeptide IX gene of human adenovirus type 3.
May 1981, Gene,
P H Seeburg, and J Shine, and J A Martial, and A Ullrich, and H M Goodman, and J D Baxter
Nucleotide sequence of the gene coding for p40, an occluded virion-specific polypeptide of Bombyx mori nuclear polyhedrosis virus.
September 1991, Journal of invertebrate pathology,
P H Seeburg, and J Shine, and J A Martial, and A Ullrich, and H M Goodman, and J D Baxter
Nucleotide sequence of the cDNA coding for human complement C1r.
August 1986, Biochemistry,
P H Seeburg, and J Shine, and J A Martial, and A Ullrich, and H M Goodman, and J D Baxter
The complete nucleotide sequence of the human gonadotropin-releasing hormone gene.
August 1989, Nucleic acids research,
P H Seeburg, and J Shine, and J A Martial, and A Ullrich, and H M Goodman, and J D Baxter
The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone.
January 1982, DNA (Mary Ann Liebert, Inc.),
Copied contents to your clipboard!