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The contents of immunoreactive somatostatin (IR-SRIF) and beta-endorphin (IR-beta-EP) in 12 brain regions were examined in rats exposed neonatally to propylthiouracil (PTU) through the mother's milk. Since the dose of PTU used in this study is lower than the usual dose employed to induce hypothyroidism, a milder form of neonatal hypothyroidism resulted. This conclusion is supported by the only mild subnormal growth of rats to adulthood and serum T4 and T3 concentrations in the normal range. Adult rats treated with PTU neonatally had significantly higher IR-SRIF contents in several brain regions compared to controls, whereas IR-beta-EP levels were not significantly different (significant increase only in the thalamus) in most regions. The results indicate that even mild hypothyroidism during early postnatal development causes permanent impairment of brain function, which manifests itself in part by an altered brain content of IR-SRIF.
N Kato, and
V C Sundmark, and
L Van Middlesworth, and
V Havlicek, and
H G Friesen
May 1983,
Life sciences,
N Kato, and
V C Sundmark, and
L Van Middlesworth, and
V Havlicek, and
H G Friesen
June 1982,
Brain research,
N Kato, and
V C Sundmark, and
L Van Middlesworth, and
V Havlicek, and
H G Friesen
March 2012,
Endocrinology,
N Kato, and
V C Sundmark, and
L Van Middlesworth, and
V Havlicek, and
H G Friesen
March 1985,
Biulleten' eksperimental'noi biologii i meditsiny,
N Kato, and
V C Sundmark, and
L Van Middlesworth, and
V Havlicek, and
H G Friesen
November 1982,
Brain research,
N Kato, and
V C Sundmark, and
L Van Middlesworth, and
V Havlicek, and
H G Friesen
December 1978,
Brain research,
N Kato, and
V C Sundmark, and
L Van Middlesworth, and
V Havlicek, and
H G Friesen
September 1986,
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons,
N Kato, and
V C Sundmark, and
L Van Middlesworth, and
V Havlicek, and
H G Friesen
July 1998,
Epilepsy research,
N Kato, and
V C Sundmark, and
L Van Middlesworth, and
V Havlicek, and
H G Friesen
December 1991,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
N Kato, and
V C Sundmark, and
L Van Middlesworth, and
V Havlicek, and
H G Friesen
March 1986,
The Journal of endocrinology,
