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The effects of protease inhibitor bacitracin on brain beta-endorphin content and analgesia, were examined in vivo. Male Sprague-Dawley rats were injected with bacitracin intracerebroventricularly and sacrificed by microwave irradiation 15 and 30 min after injection. Brain beta-endorphin levels were 27% higher in bacitracin treated rats than in controls. A second group of bacitracin injected rats was subjected to continuous intermittent 55 degrees C hot plate exposure. Bacitracin-injected rats exhibited total analgesia 15 min after bacitracin injection. At 30 min, this analgesic effect subsided. Control rats exhibited no analgesia. Bacitracin induced analgesia was naloxone reversible at a low dose of naloxone (1 mg/kg). At a higher dose of naloxone (10mg/kg), bacitracin induced analgesia was only partially antagonized. These results suggest that bacitracin induced analgesia might be due to the elevated levels of brain beta-endorphin caused by a decrease in its breakdown by bacitracin.
G Sikand, and
V Havlicek
May 1983,
Life sciences,
G Sikand, and
V Havlicek
May 1984,
Proceedings of the National Academy of Sciences of the United States of America,
G Sikand, and
V Havlicek
October 1982,
Neuroendocrinology,
G Sikand, and
V Havlicek
July 1989,
Brain research,
G Sikand, and
V Havlicek
June 1982,
Endocrinology,
G Sikand, and
V Havlicek
July 1978,
Horumon to rinsho. Clinical endocrinology,
G Sikand, and
V Havlicek
February 1986,
Psychological medicine,
G Sikand, and
V Havlicek
April 1986,
Fertility and sterility,
G Sikand, and
V Havlicek
January 1988,
Neuroendocrinology,
