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A series of glycolipid antigens reacting with the monoclonal antibody directed to the stage-specific embryonic antigen 1 was isolated and characterized from group O human erythrocyte membranes. A ceramide heptasaccharide (Structure 1), ceramide nonasaccharide (Structure 2), and ceramide decasaccharide (Structure 3) have been characterized (formula, see text) The main feature of this glycolipid series is its long core sugar chain with a nonbranched repeating N-acetyllactosamine (norpolylactosamine). This characteristic is in contrast to that of co-existing H-active glycolipid series in which the longer core structures are branched type repeating N-acetyllactosamine (isopolylactosamine). The reactivity of these glycolipids to monoclonal anti-stage-specific embryonic antigen 1 antibody varied proportionately to the length of their core sugar chains. A possible significance of these glycolipids as developmentally regulated antigens and as cancer-associated antigens was discussed.
R Kannagi, and
E Nudelman, and
S B Levery, and
S Hakomori
July 1983,
The Journal of biological chemistry,
R Kannagi, and
E Nudelman, and
S B Levery, and
S Hakomori
November 1980,
Biochemical and biophysical research communications,
R Kannagi, and
E Nudelman, and
S B Levery, and
S Hakomori
November 1978,
Proceedings of the National Academy of Sciences of the United States of America,
R Kannagi, and
E Nudelman, and
S B Levery, and
S Hakomori
June 1981,
Biochemical and biophysical research communications,
R Kannagi, and
E Nudelman, and
S B Levery, and
S Hakomori
November 1999,
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience,
R Kannagi, and
E Nudelman, and
S B Levery, and
S Hakomori
August 1990,
Biochemical and biophysical research communications,
R Kannagi, and
E Nudelman, and
S B Levery, and
S Hakomori
January 1989,
Leukemia research,
R Kannagi, and
E Nudelman, and
S B Levery, and
S Hakomori
July 1993,
Japanese journal of cancer research : Gann,
R Kannagi, and
E Nudelman, and
S B Levery, and
S Hakomori
June 1987,
Hybridoma,
R Kannagi, and
E Nudelman, and
S B Levery, and
S Hakomori
September 1988,
The Journal of biological chemistry,
