Biomaterial Database

Cholic and chenodeoxycholic acids during drainage of cholestasis in man with and without bile refeeding. Determination of serum and urinary concentrations by radioimmunoassay. 1983

A Norlander, and A Norman, and K Samuelson, and R Sundblad

Non-sulphated conjugates of cholic (C) and chenodeoxycholic (CDC) acids in serum and total conjugates in urine were determined by radioimmunoassay during drainage of extrahepatic cholestasis in twelve patients studied under three different situations: without refeeding of bile, with refeeding after a delay of one to eight days, and with immediate refeeding. The changes in the serum concentrations and renal excretion of C and CDC varied considerably between patients, but the following general features could be discerned: In patients without bile refeeding but with external drainage, the serum concentrations and renal excretion of C and CDC decreased rapidly. In patients with delayed bile refeeding during drainage, the serum concentrations of C and CDC increased when refeeding of bile was begun but only slightly and temporarily, and no influence on renal excretion could be observed. In patients with immediate bile refeeding through an internal drainage the serum concentrations decreased slowly and renal excretion increased during the first week. These differences in the pattern of serum bile acid concentrations were not reflected in the serum concentrations of bilirubin, alkaline phosphatase, alanine aminotransferase or gamma glutamyltransferase.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011863	Radioimmunoassay	Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.	Radioimmunoassays
D002635	Chenodeoxycholic Acid	A bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.	Chenic Acid,Chenodeoxycholate,Chenodiol,Gallodesoxycholic Acid,Chenique Acid,Chenix,Chenofalk,Chenophalk,Henohol,Quenobilan,Quenocol,Sodium Chenodeoxycholate,Acid, Chenic,Acid, Chenique,Acid, Chenodeoxycholic,Acid, Gallodesoxycholic,Chenodeoxycholate, Sodium
D002793	Cholic Acids	The 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholanic acid family of bile acids in man, usually conjugated with glycine or taurine. They act as detergents to solubilize fats for intestinal absorption, are reabsorbed by the small intestine, and are used as cholagogues and choleretics.	Cholalic Acids,Acids, Cholalic,Acids, Cholic
D004322	Drainage	The removal of fluids or discharges from the body, such as from a wound, sore, or cavity.
D005260	Female		Females
D005723	gamma-Glutamyltransferase	An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.	GGTP,Glutamyl Transpeptidase,gammaglutamyltransferase,gamma-Glutamyl Transpeptidase,Transpeptidase, Glutamyl,Transpeptidase, gamma-Glutamyl,gamma Glutamyl Transpeptidase,gamma Glutamyltransferase
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly