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The beta-adrenergic stimulation of adenylate cyclase in membranes from human auricles, ventricles, and fetal heart was compared with the binding properties of beta-adrenergic receptors in human auricles. In terms of adenylate cyclase activation, three full agonists (isoproterenol, epinephrine, and norepinephrine), four partial agonists (procaterol, salbutamol, fenoterol, and zinterol), and four antagonists (propranolol, metoprolol, atenolol, and practolol) were tested. The beta-adrenergic activation of adenylate cyclase in membranes from rat heart (with a majority of beta 1-adrenergic receptors), rat erythrocytes, and rat reticulocytes (with a homogeneous population of beta 2-adrenergic receptors) served as reference. The reactivity of human heart adenylate cyclase, estimated by the Kact or Ki values of 11 beta-adrenergic agents, indicated that the activation of this enzyme occurred through receptors of the beta 2-subtype only. Receptors of the beta 1-subtype (50% of the total population) were not coupled to the enzyme.
M Waelbroeck, and
G Taton, and
M Delhaye, and
P Chatelain, and
J C Camus, and
R Pochet, and
J L Leclerc, and
J M De Smet, and
P Robberecht, and
J Christophe
July 1986,
Physiological reviews,
M Waelbroeck, and
G Taton, and
M Delhaye, and
P Chatelain, and
J C Camus, and
R Pochet, and
J L Leclerc, and
J M De Smet, and
P Robberecht, and
J Christophe
March 1991,
Investigative ophthalmology & visual science,
M Waelbroeck, and
G Taton, and
M Delhaye, and
P Chatelain, and
J C Camus, and
R Pochet, and
J L Leclerc, and
J M De Smet, and
P Robberecht, and
J Christophe
September 1986,
The Journal of pharmacology and experimental therapeutics,
M Waelbroeck, and
G Taton, and
M Delhaye, and
P Chatelain, and
J C Camus, and
R Pochet, and
J L Leclerc, and
J M De Smet, and
P Robberecht, and
J Christophe
September 1993,
The Journal of experimental biology,
M Waelbroeck, and
G Taton, and
M Delhaye, and
P Chatelain, and
J C Camus, and
R Pochet, and
J L Leclerc, and
J M De Smet, and
P Robberecht, and
J Christophe
September 1975,
Biochemical pharmacology,
M Waelbroeck, and
G Taton, and
M Delhaye, and
P Chatelain, and
J C Camus, and
R Pochet, and
J L Leclerc, and
J M De Smet, and
P Robberecht, and
J Christophe
January 1976,
Recent progress in hormone research,
M Waelbroeck, and
G Taton, and
M Delhaye, and
P Chatelain, and
J C Camus, and
R Pochet, and
J L Leclerc, and
J M De Smet, and
P Robberecht, and
J Christophe
March 1975,
Biochemical pharmacology,
M Waelbroeck, and
G Taton, and
M Delhaye, and
P Chatelain, and
J C Camus, and
R Pochet, and
J L Leclerc, and
J M De Smet, and
P Robberecht, and
J Christophe
April 1986,
The Journal of pharmacology and experimental therapeutics,
M Waelbroeck, and
G Taton, and
M Delhaye, and
P Chatelain, and
J C Camus, and
R Pochet, and
J L Leclerc, and
J M De Smet, and
P Robberecht, and
J Christophe
February 1992,
General and comparative endocrinology,
M Waelbroeck, and
G Taton, and
M Delhaye, and
P Chatelain, and
J C Camus, and
R Pochet, and
J L Leclerc, and
J M De Smet, and
P Robberecht, and
J Christophe
January 1980,
The Journal of clinical endocrinology and metabolism,
