-transparent.png){kind=logo}
We compared the influences of pretreatment with the narcotic antagonist drug naloxone and the neuropeptide L-prolyl-L-leucyl-glycinamide (PLG) upon apomorphine-induced stereotypic climbing activity in mice and apomorphine-induced contralateral rotational behavior in rats with unilateral 6-hydroxydopamine lesions of the substantia nigra. Naloxone produced dose-related potentiation in the mouse climbing model, while PLG was without effect. On the other hand, PLG produced dose-related potentiation in the rat rotational paradigm, while naloxone was without appreciable influence. These findings show an asymmetrical potentiation of apomorphine by naloxone and PLG in these two standard experimental models of striatal dopaminergic activity.
R M Quock, and
T S Lucas, and
T J Hartl
January 1979,
European journal of pharmacology,
R M Quock, and
T S Lucas, and
T J Hartl
November 1982,
Pharmacology, biochemistry, and behavior,
R M Quock, and
T S Lucas, and
T J Hartl
September 1978,
Pharmacology, biochemistry, and behavior,
R M Quock, and
T S Lucas, and
T J Hartl
August 1980,
Naunyn-Schmiedeberg's archives of pharmacology,
R M Quock, and
T S Lucas, and
T J Hartl
December 1981,
Science (New York, N.Y.),
R M Quock, and
T S Lucas, and
T J Hartl
January 1980,
Peptides,
R M Quock, and
T S Lucas, and
T J Hartl
January 1983,
Methods and findings in experimental and clinical pharmacology,
R M Quock, and
T S Lucas, and
T J Hartl
September 1984,
Pharmacology, biochemistry, and behavior,
R M Quock, and
T S Lucas, and
T J Hartl
May 1981,
European journal of pharmacology,
R M Quock, and
T S Lucas, and
T J Hartl
December 1986,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
