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Accumulating evidence suggests that there is an increase in the density (maximum binding sites) of striatal dopamine receptors in the central nervous system of spontaneously hypertensive rats (SHR). A tripeptide of hypothalamic origin, PLG (L-Prolyl-L-Leucyl-Glycinamide) has been found to have modulatory effect on the dopamine receptors in the central nervous system of rats. Two analogues of PLG with cyclic amino-acid residues, L-Prolyl-L-Leucyl-(-)-thiazolidine-2-carboxamide and L-Prolyl-L-Leucyl-(+)-thiazolidine-2-carboxamide, have shown antihypertensive effect at the established phase of hypertension in 16-week old SHRs at a dose of 35 mg/kg per day per 7 days i.p. It was also observed from studies of radioligand [3H]-spiroperidol binding that the laevo-isomer of the PLG analogue has down-regulated the up-regulated dopamine receptors. Our findings confirm the role of central dopaminergic pathways in the pathogenesis of hypertension in SHR.
G Rajakumar, and
A N Singh, and
F Naas, and
S Chiu, and
C Y Kwan, and
R L Johnson, and
R K Mishra
June 1986,
International journal of peptide and protein research,
G Rajakumar, and
A N Singh, and
F Naas, and
S Chiu, and
C Y Kwan, and
R L Johnson, and
R K Mishra
January 1983,
Methods and findings in experimental and clinical pharmacology,
G Rajakumar, and
A N Singh, and
F Naas, and
S Chiu, and
C Y Kwan, and
R L Johnson, and
R K Mishra
January 1979,
European journal of pharmacology,
G Rajakumar, and
A N Singh, and
F Naas, and
S Chiu, and
C Y Kwan, and
R L Johnson, and
R K Mishra
November 1982,
Pharmacology, biochemistry, and behavior,
G Rajakumar, and
A N Singh, and
F Naas, and
S Chiu, and
C Y Kwan, and
R L Johnson, and
R K Mishra
January 1980,
Peptides,
G Rajakumar, and
A N Singh, and
F Naas, and
S Chiu, and
C Y Kwan, and
R L Johnson, and
R K Mishra
August 1985,
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry,
G Rajakumar, and
A N Singh, and
F Naas, and
S Chiu, and
C Y Kwan, and
R L Johnson, and
R K Mishra
August 1999,
Bioorganic & medicinal chemistry letters,
G Rajakumar, and
A N Singh, and
F Naas, and
S Chiu, and
C Y Kwan, and
R L Johnson, and
R K Mishra
January 1987,
Peptides,
G Rajakumar, and
A N Singh, and
F Naas, and
S Chiu, and
C Y Kwan, and
R L Johnson, and
R K Mishra
July 1983,
Pharmacology, biochemistry, and behavior,
G Rajakumar, and
A N Singh, and
F Naas, and
S Chiu, and
C Y Kwan, and
R L Johnson, and
R K Mishra
November 1976,
Life sciences,
