-transparent.png){kind=logo}
Plasma gonadotropins, prolactin and hypothalamic tyrosine hydroxylase (TH) activity were evaluated at 15 and 30 min after third ventricular injection of bombesin at doses of 100 or 1000 ng and secretin at doses of 1000 and 5000 ng in ovariectomized (OVX) unanesthetized rats. Bombesin had no effect on plasma gonadotropin levels. Intraventricular injection of either 100 or 1000 ng dose of bombesin significantly suppressed prolactin levels with parallel elevation in hypothalamic TH activity and there appears to be no dose response relationship. Secretin at 1000 ng dose, significantly lowered plasma LH and PRL levels and elevated hypothalamic TH activity whereas a 5000 ng dose increased PRL concentrations but had no effect on gonadotropin levels and hypothalamic TH activity. Bombesin appears to be a potent inhibitor of PRL release in OVX, conscious rats and this effect may be mediated via hypothalamic dopamine. Lower dose of secretin appears to inhibit PRL release by possibly activating the hypothalamic dopaminergic system, while at higher dose peripheral activation results in enhanced prolactin release.
G N Babu, and
E Vijayan
August 1981,
Life sciences,
G N Babu, and
E Vijayan
May 1983,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
G N Babu, and
E Vijayan
January 1977,
Neuroendocrinology,
G N Babu, and
E Vijayan
November 1975,
The Journal of endocrinology,
G N Babu, and
E Vijayan
January 1980,
Brain research bulletin,
G N Babu, and
E Vijayan
August 1997,
Neuroscience letters,
G N Babu, and
E Vijayan
January 1974,
Neuroendocrinology,
G N Babu, and
E Vijayan
November 1978,
Life sciences,
G N Babu, and
E Vijayan
June 1990,
Endocrinology,
G N Babu, and
E Vijayan
February 2002,
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
